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  • Han, Young JooSungkyunkwan Univ, South Korea (author)

Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • IVYSPRING INT PUBL,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-171952
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171952URI
  • https://doi.org/10.7150/thno.48342DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145189963URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-beta 1b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lee, Keum HwaYonsei Univ, South Korea (author)
  • Yoon, SojungYonsei Univ, South Korea (author)
  • Nam, Seoung WanYonsei Univ, South Korea (author)
  • Ryu, SeohyunYonsei Univ, South Korea (author)
  • Seong, DawonYonsei Univ, South Korea (author)
  • Kim, Jae SeokYonsei Univ, South Korea (author)
  • Lee, Jun YoungYonsei Univ, South Korea (author)
  • Yang, Jae WonYonsei Univ, South Korea (author)
  • Lee, JinheeYonsei Univ, South Korea (author)
  • Koyanagi, AiUniv Barcelona, Spain; ICREA, Spain (author)
  • Hong, Sung HwiHarvard TH Chan Sch Publ Hlth, MA USA (author)
  • Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71 (author)
  • Radua, JoaquimKarolinska Institutet (author)
  • Smith, LeeAnglia Ruskin Univ, England (author)
  • Oh, HansUniv Southern Calif, CA 90089 USA (author)
  • Abou Ghayda, RamyHarvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA (author)
  • Kronbichler, AndreasMed Univ Innsbruck, Austria (author)
  • Effenberger, MariaMed Univ Innsbruck, Austria (author)
  • Kresse, DanielaSt Johann Cty Hosp, Austria (author)
  • Denicolo, SaraMed Univ Innsbruck, Austria (author)
  • Kang, WoosunUniv Illinois, IL USA (author)
  • Jacob, LouisUniv Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France (author)
  • Shin, HanwulYonsei Univ, South Korea (author)
  • Shin, Jae IlYonsei Univ, South Korea (author)
  • Sungkyunkwan Univ, South KoreaYonsei Univ, South Korea (creator_code:org_t)

Related titles

  • In:Theranostics: IVYSPRING INT PUBL11:3, s. 1207-12311838-7640

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