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Treatment of severe...
Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials
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- Han, Young Joo (författare)
- Sungkyunkwan Univ, South Korea
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- Lee, Keum Hwa (författare)
- Yonsei Univ, South Korea
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- Yoon, Sojung (författare)
- Yonsei Univ, South Korea
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- Nam, Seoung Wan (författare)
- Yonsei Univ, South Korea
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- Ryu, Seohyun (författare)
- Yonsei Univ, South Korea
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- Seong, Dawon (författare)
- Yonsei Univ, South Korea
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- Kim, Jae Seok (författare)
- Yonsei Univ, South Korea
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- Lee, Jun Young (författare)
- Yonsei Univ, South Korea
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- Yang, Jae Won (författare)
- Yonsei Univ, South Korea
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- Lee, Jinhee (författare)
- Yonsei Univ, South Korea
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- Koyanagi, Ai (författare)
- Univ Barcelona, Spain; ICREA, Spain
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- Hong, Sung Hwi (författare)
- Harvard TH Chan Sch Publ Hlth, MA USA
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- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Radua, Joaquim (författare)
- Karolinska Institutet
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- Smith, Lee (författare)
- Anglia Ruskin Univ, England
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- Oh, Hans (författare)
- Univ Southern Calif, CA 90089 USA
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- Abou Ghayda, Ramy (författare)
- Harvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA
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- Kronbichler, Andreas (författare)
- Med Univ Innsbruck, Austria
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- Effenberger, Maria (författare)
- Med Univ Innsbruck, Austria
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- Kresse, Daniela (författare)
- St Johann Cty Hosp, Austria
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- Denicolo, Sara (författare)
- Med Univ Innsbruck, Austria
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- Kang, Woosun (författare)
- Univ Illinois, IL USA
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- Jacob, Louis (författare)
- Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France
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- Shin, Hanwul (författare)
- Yonsei Univ, South Korea
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- Shin, Jae Il (författare)
- Yonsei Univ, South Korea
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(creator_code:org_t)
- IVYSPRING INT PUBL, 2021
- 2021
- Engelska.
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Ingår i: Theranostics. - : IVYSPRING INT PUBL. - 1838-7640. ; 11:3, s. 1207-1231
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-beta 1b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- COVID-19; therapeutic agent; SARS; MERS; mortality; coronavirus
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Han, Young Joo
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Lee, Keum Hwa
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Yoon, Sojung
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Nam, Seoung Wan
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Ryu, Seohyun
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Seong, Dawon
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visa fler...
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Kim, Jae Seok
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Lee, Jun Young
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Yang, Jae Won
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Lee, Jinhee
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Koyanagi, Ai
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Hong, Sung Hwi
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Dragioti, Elena
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Radua, Joaquim
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Smith, Lee
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Oh, Hans
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Abou Ghayda, Ram ...
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Kronbichler, And ...
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Effenberger, Mar ...
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Kresse, Daniela
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Denicolo, Sara
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Kang, Woosun
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Jacob, Louis
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Shin, Hanwul
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Shin, Jae Il
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Theranostics
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet