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Serotype Is Associa...
Serotype Is Associated With High Rate of Colistin Resistance Among Clinical Isolates of Salmonella
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- Luo, Qixia (författare)
- Zhejiang Univ, Peoples R China
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- Wang, Yuan (författare)
- Zhejiang Univ, Peoples R China
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- Fu, Hao (författare)
- Zhejiang Univ, Peoples R China
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- Yu, Xiao (författare)
- Zhejiang Univ, Peoples R China
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- Zheng, Beiwen (författare)
- Zhejiang Univ, Peoples R China
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- Chen, Yunbo (författare)
- Zhejiang Univ, Peoples R China
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- Berglund, Björn (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Zhejiang Univ, Peoples R China
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- Xiao, Yonghong (författare)
- Zhejiang Univ, Peoples R China
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(creator_code:org_t)
- 2020-12-18
- 2020
- Engelska.
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Ingår i: Frontiers in Microbiology. - : FRONTIERS MEDIA SA. - 1664-302X. ; 11
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- To investigate the prevalence, probable mechanisms and serotype correlation of colistin resistance in clinical isolates of Salmonella from patients in China, Salmonella isolates were collected from fecal and blood samples of patients. In this study, 42.8% (136/318) clinical isolated Salmonella were resistant to colistin. MIC distribution for colistin at serotype level among the two most prevalent serotypes originating from humans in China indicated that Salmonella Enteritidis (83.9% resistance, 125/149) were significantly less susceptible than Salmonella Typhimurium (15.3% resistance, 9/59, P < 0.01). mcr genes and mutations in PmrAB confer little for rate of colistin resistant Salmonella isolated from human patients. Phylogenetic tree based on core-genome single nucleotide polymorphisms (SNPs) was separately by the serotypes and implied a diffused distribution of MICs in the same serotype isolates. Relatvie expression levels of colistin resistant related pmr genes were significantly higher in non-mcr colistin resistant S. Typhimurium than in colistin sensitive S. Typhimurium, but no discernable differences between colistin resistant and sensitive S. Enteritidis, indicating a different mechanism between colistin resistant S. Typhimurium and S. Enteritidis. In conclusion, colistin susceptibility and colistin resistant mechanism of clinical isolated Salmonella were closely associated with specific serotypes, at least in the two most prevalent serotype Enteritidis and Typhimurium. We suggest clinical microbiology laboratory interpreting Salmonella colistin MIC results in the serotype level.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Salmonella enterica; serotype; colistin susceptibility; clinical isolates; phylogenetic analysis; pmr genes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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