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Risk factors of COV...
Risk factors of COVID-19 mortality: a systematic review of current literature and lessons from recent retracted articles
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- Lee, K. H. (author)
- Yonsei Univ, South Korea
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- Kim, J. S. (author)
- Yonsei Univ, South Korea
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- Hong, S. H. (author)
- Harvard TH Chan Sch Publ Hlth, MA USA; Yonsei Univ, South Korea
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- Seong, D. (author)
- Yonsei Univ, South Korea
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- Choi, Y. R. (author)
- Yonsei Univ, South Korea
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- Ahn, Y. T. (author)
- Yonsei Univ, South Korea
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- Kim, K. S. (author)
- Yonsei Univ, South Korea
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- Kim, S. E. (author)
- Yonsei Univ, South Korea
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- Lee, S. (author)
- Yonsei Univ, South Korea; Sejong Univ, South Korea
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- Sim, W. (author)
- Yonsei Univ, South Korea
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- Kim, D. (author)
- Yonsei Univ, South Korea
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- Jun, B. (author)
- Yonsei Univ, South Korea
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- Yang, J. W. (author)
- Yonsei Univ, South Korea
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- Yon, D. K. (author)
- CHA Univ, South Korea; Seoul Natl Univ, South Korea
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- Lee, S. W. (author)
- Sejong Univ, South Korea
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- Kim, M. S. (author)
- Korea Univ, South Korea; Minist Hlth & Welf, South Korea
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- Dragioti, Elena (author)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Li, H. (author)
- Univ Florida, FL USA
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- Jacob, L. (author)
- Univ Versailles St Quentin En Yvelines, France; Parc Sanitari St Joan de Deu, Spain
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- Koyanagi, A. (author)
- Parc Sanitari St Joan de Deu, Spain; ICREA, Spain
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- Abou Ghayda, R. (author)
- Harvard TH Chan Sch Publ Hlth, MA USA; Case Western Reserve Univ, OH USA
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- Shin, J. I (author)
- Yonsei Univ, South Korea
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- Smith, L. (author)
- Anglia Ruskin Univ, England
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(creator_code:org_t)
- VERDUCI PUBLISHER, 2020
- 2020
- English.
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In: European Review for Medical and Pharmacological Sciences. - : VERDUCI PUBLISHER. - 1128-3602. ; 24:24, s. 13089-13097
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE: Recently, two influential articles that reported the association of (hydroxy)chloroquine or angiotensin converting enzyme (ACE) inhibitors and coronavirus disease 2019 (COVID-19) mortality were retracted due to significant methodological issues. Therefore, we aimed to analyze the same clinical issues through an improved research method and to find out the differences from the retracted papers. We systematically reviewed pre-existing literature, and compared the results with those of the retracted papers to gain a novel insight. MATERIALS AND METHODS: We extracted common risk factors identified in two retracted papers, and conducted relevant publication search until June 26, 2020 in PubMed. Then, we analyzed the risk factors for COVID-19 mortality and compared them to those of the retracted papers. RESULTS: Our systematic review demonstrated that most demographic and clinical risk factors for COVID-19 mortality were similar to those of the retracted papers. However, while the retracted paper indicated that both (hydroxy)chloroquine monotherapy and combination therapy with macrolide were associated with higher risk of mortality, our study showed that only combination therapy of hydroxychloroquine and macrolide was associated with higher risk of mortality (odds ratio 2.33; 95% confidence interval 1.63-3.34). In addition, our study demonstrated that use of ACE inhibitors or angiotensin receptor blockers (ARBs) was associated with reduced risk of mortality (0.77; 0.65-0.91). CONCLUSIONS: When analyzing the same clinical issues with the two retracted papers through a systematic review of randomized controlled trials and relevant cohort studies. we found out that (hydroxy)chloroquine monotherapy was not associated with higher risk of mortality, and that the use of ACE inhibitors or ARBs was associated with reduced risk of mortality in COVID-19 patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- COVID-19; Risk factors; Mortality
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Lee, K. H.
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Kim, J. S.
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Hong, S. H.
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Seong, D.
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Choi, Y. R.
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Ahn, Y. T.
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Kim, K. S.
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Kim, S. E.
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Lee, S.
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Sim, W.
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Kim, D.
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Jun, B.
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Yang, J. W.
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Yon, D. K.
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Lee, S. W.
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Kim, M. S.
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Dragioti, Elena
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Li, H.
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Jacob, L.
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Koyanagi, A.
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Abou Ghayda, R.
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Shin, J. I
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Smith, L.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Review ...
- By the university
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Linköping University