Sökning: WFRF:(Berggren Magnus 1968 )
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Design and Operatio...
Design and Operation of Hybrid Microfluidic Iontronic Probes for Regulated Drug Delivery
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- Arbring Sjöström, Theresia, 1987- (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Ivanov, Anton I. (författare)
- INSERM, INS, Inst Neurosci Syst, Aix Marseille University, Marseille, France
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- Bernard, Christophe (författare)
- INSERM, INS, Inst Neurosci Syst, Aix Marseille University, Marseille, France
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- Tybrandt, Klas, 1982- (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Poxson, David (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Simon, Daniel T, 1978- (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Berggren, Magnus, 1968- (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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(creator_code:org_t)
- 2021-01-14
- 2021
- Engelska.
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Ingår i: Advanced Materials Technologies. - Hoboken, New Jersey : John Wiley & Sons. - 2365-709X. ; 6:2
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Highly controlled drug delivery devices play an increasingly important role in the development of new neuroengineering tools. Stringent - and sometimes contradicting - demands are placed on such devices, ranging from robustness in freestanding devices, to overall device miniaturization, while maintaining precise spatiotemporal control of delivery with high chemical specificity and high on/off ratio. Here, design principles of a hybrid microfluidic iontronic probe that uses flow for long-range pressure-driven transport in combination with an iontronic tip that provides electronically fine-tuned pressure-free delivery are explored. Employing a computational model, the effects of decoupling the drug reservoir by exchanging a large passive reservoir with a smaller microfluidic system are reported. The transition at the microfluidic-iontronic interface is found to require an expanded ion exchange membrane inlet in combination with a constant fluidic flow, to allow a broad range of device operation, including low source concentrations and high delivery currents. Complementary to these findings, the free-standing hybrid probe monitored in real time by an external sensor is demonstrated. From these computational and experimental results, key design principles for iontronic devices are outlined that seek to use the efficient transport enabled by microfluidics, and further, key observations of hybrid microfluidic iontronic probes are explained.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- bioelectronics
- drug delivery
- iontronics
- microfluidics
- organic electronics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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