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Risk Stratification of Patients With Apparently Idiopathic Premature Ventricular Contractions A Multicenter International CMR Registry
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- Muser, Daniele (author)
- Hosp Univ Penn, PA 19104 USA; Santa Maria della Misericordia Univ Hosp, Italy
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- Santangeli, Pasquale (author)
- Hosp Univ Penn, PA 19104 USA
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- Castro, Simon A. (author)
- Hosp Univ Penn, PA 19104 USA
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- Arroyo, Ruben Casado (author)
- Univ Libre Bruxelles, Belgium
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- Maeda, Shingo (author)
- Tokyo Med & Dent Univ, Japan
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- Benhayon, Daniel A. (author)
- Mem Healthcare Syst, FL USA
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- Liuba, Ioan (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Liang, Jackson J. (author)
- Hosp Univ Penn, PA 19104 USA
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- Sadek, Mouhannad M. (author)
- Univ Ottawa, Canada
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- Chahal, Anwar (author)
- Hosp Univ Penn, PA 19104 USA
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- Magnani, Silvia (author)
- NYU, NY USA
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- Pieroni, Maurizio (author)
- San Donato Hosp, Italy
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- Santarossa, Elena (author)
- Santa Maria della Misericordia Univ Hosp, Italy
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- Desjardins, Benoit (author)
- Hosp Univ Penn, PA 19104 USA
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- Dixit, Sanjay (author)
- Hosp Univ Penn, PA 19104 USA
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- Garcia, Fermin C. (author)
- Hosp Univ Penn, PA 19104 USA
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- Callans, David J. (author)
- Hosp Univ Penn, PA 19104 USA
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- Frankel, David S. (author)
- Hosp Univ Penn, PA 19104 USA
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- Alavi, Abass (author)
- Hosp Univ Penn, PA 19104 USA
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- Marchlinski, Francis E. (author)
- Hosp Univ Penn, PA 19104 USA
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- Selvanayagam, Joseph B. (author)
- Flinders Med Ctr, Australia
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- Nucifora, Gaetano (author)
- Flinders Med Ctr, Australia; Manchester Univ NHS Fdn Trust, England
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(creator_code:org_t)
- ELSEVIER, 2020
- 2020
- English.
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In: JACC. - : ELSEVIER. - 2405-500X .- 2405-5018. ; 6:6, s. 722-735
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVES This study investigated the prevalence and prognostic significance of concealed myocardial abnormalities identified by cardiac magnetic resonance (CMR) imaging in patients with apparently idiopathic premature ventricular contractions (PVCs). BACKGROUND The rote of CMR imaging in patients with frequent PVCs and otherwise negative diagnostic workup is uncertain. METHODS This was a multicenter, international study that included 518 patients (age 44 +/- 15 years; 57% men) with frequent (>1,000/24 h) PVCs and negative routine diagnostic workup. Patients underwent a comprehensive CMR protocol including late gadolinium enhancement imaging for detection of necrosis and/or fibrosis. The study endpoint was a composite of sudden cardiac death, resuscitated cardiac arrest, and nonfatal episodes of ventricular fibrillation or sustained ventricular tachycardia that required appropriate implantable cardioverter-defibrillator therapy. RESULTS Myocardial abnormalities were found in 85 (16%) patients. Mate gender (odds ratio [OR]: 4.28; 95% confidence interval [CI]: 2.06 to 8.93; p = 0.01), family history of sudden cardiac death and/or cardiomyopathy (OR: 3.61; 95% CI: 1.33 to 9.82; p = 0.01), multifocat PVCs (OR: 11.12; 95% CI: 4.35 to 28.46; p < 0.01), and non-left bundle branch block inferior axis morphology (OR: 14.11; 95% CI: 7.35 to 27.07; p < 0.01) were alt significantly related to the presence of myocardial abnormalities. After a median follow-up of 67 months, the composite endpoint occurred in 26 (5%) patients. Subjects with myocardial abnormalities on CMR had a higher incidence of the composite outcome (n = 25; 29%) compared with those without abnormalities (n = 1; 0.2%; p < 0.01). CONCLUSIONS CMR can identify concealed myocardial abnormalities in 16% of patients with apparently idiopathic frequent PVCs. Presence of myocardial abnormalities on CMR predict worse clinical outcomes. (C) 2019 by the American College of Cardiology Foundation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiac magnetic resonance; premature ventricular contractions; sudden cardiac death; ventricular tachycardia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Muser, Daniele
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Santangeli, Pasq ...
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Castro, Simon A.
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Arroyo, Ruben Ca ...
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Maeda, Shingo
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Benhayon, Daniel ...
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show more...
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Liuba, Ioan
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Liang, Jackson J ...
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Sadek, Mouhannad ...
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Chahal, Anwar
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Magnani, Silvia
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Pieroni, Maurizi ...
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Santarossa, Elen ...
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Desjardins, Beno ...
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Dixit, Sanjay
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Garcia, Fermin C ...
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Callans, David J ...
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Frankel, David S ...
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Alavi, Abass
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Marchlinski, Fra ...
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Selvanayagam, Jo ...
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Nucifora, Gaetan ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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JACC
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Linköping University