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Cardiac Myosin Acti...
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure
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- Teerlink, John R. (författare)
- San Francisco VA Med Ctr, CA 94143 USA; Univ Calif San Francisco, CA 94143 USA
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- Diaz, Rafael (författare)
- Estudios Clin Latino Amer, Argentina
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- Felker, G. Michael (författare)
- Duke Univ, NC 27706 USA; Duke Clin Res Inst, NC USA; Natl & Kapodistrian Univ Athens, Greece
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- McMurray, John J. V. (författare)
- British Heart Fdn, England
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- Metra, Marco (författare)
- Univ Brescia, Italy
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- Solomon, Scott D. (författare)
- Brigham & Womens Hosp, MA 02115 USA
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- Adams, Kirkwood F. (författare)
- Univ N Carolina, NC 27515 USA
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- Anand, Inder (författare)
- Univ Minnesota, MN USA
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- Arias-Mendoza, Alexandra (författare)
- Inst Nacl Cardiol, Mexico
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- Biering-Sorensen, Tor (författare)
- Univ Copenhagen, Denmark; Univ Copenhagen, Denmark
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- Bohm, Michael (författare)
- Saarland Univ, Germany
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- Bonderman, Diana (författare)
- Med Univ Vienna, Austria
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- Cleland, John G. F. (författare)
- Univ Glasgow, Scotland; Imperial Coll, England; Univ Nova Lisboa, Portugal
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- Corbalan, Ramon (författare)
- Pontificia Univ Catolicica Chile, Spain
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- Crespo-Leiro, Maria G. (författare)
- Univ A Coruna, Spain
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- Dahlström, Ulf (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Echeverria, Luis E. (författare)
- Fdn Cardiovasc & Colombia, Colombia
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- Fang, James C. (författare)
- Univ Utah, UT USA
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- Filippatos, Gerasimos (författare)
- National and Kapodistrian University of Athens, Attikon University Hospital, Greece; Athens, Greece
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- Fonseca, Candida (författare)
- Hospital S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal
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- Goncalvesova, Eva (författare)
- Comenius Univ, Slovakia
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- Goudev, Assen R. (författare)
- Queen Giovanna Univ Hosp & Med Univ, Bulgaria
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- Howlett, Jonathan G. (författare)
- Univ Calgary, Canada
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- Lanfear, David E. (författare)
- Henry Ford Hosp, MI 48202 USA
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- Li, Jing (författare)
- Chinese Acad Med Sci & Peking Union Med Coll, Peoples R China
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- Lund, Mayanna (författare)
- Middlemore Hosp, New Zealand
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- Macdonald, Peter (författare)
- St Vincents Hosp Sydney, Australia
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- Mareev, Viacheslav (författare)
- Moscow MV Lomonosov State Univ, Russia
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- Momomura, Shin-ichi (författare)
- Saitama Citizens Med Ctr, Japan
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- OMeara, Eileen (författare)
- Montreal Heart Inst, Canada; Univ Montreal, Canada
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- Parkhomenko, Alexander (författare)
- Section of Cardiology, San Francisco Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, San Francisco, United States; Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United Kingdom
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- Ponikowski, Piotr (författare)
- Wroclaw Med Univ, Poland
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- Ramires, Felix J. A. (författare)
- Univ Sao Paulo, Brazil
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- Serpytis, Pranas (författare)
- Vilnius Univ, Lithuania
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- Sliwa, Karen (författare)
- Univ Cape Town, South Africa
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- Spinar, Jindrich (författare)
- St Ann Hosp, Czech Republic; Masaryk Univ Brno, Czech Republic
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- Suter, Thomas M. (författare)
- Univ Bern, Switzerland
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- Tomcsanyi, Janos (författare)
- St John God Hosp, Hungary
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- Vandekerckhove, Hans (författare)
- AZ St Lucas, Belgium
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- Vinereanu, Dragos (författare)
- Univ & Emergency Hosp, Romania
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- Voors, Adriaan A. (författare)
- Univ Groningen, Netherlands
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- Yilmaz, Mehmet B. (författare)
- Dokuz Eylul Univ, Turkey
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- Zannad, Faiez (författare)
- Section of Cardiology, San Francisco Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, San Francisco, United States; Fundación Cardiovascular de Colombia, Floridablanca, Colombia
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- Sharpsten, Lucie (författare)
- Amgen Inc, CA USA
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- Legg, Jason C. (författare)
- Amgen Inc, CA USA
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- Varin, Claire (författare)
- Univ Lorraine, France
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- Honarpour, Narimon (författare)
- Amgen Inc, CA USA
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- Abbasi, Siddique A. (författare)
- Amgen Inc, CA USA
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- Malik, Fady I. (författare)
- Cytokinetics, CA USA
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- Kurtz, Christopher E. (författare)
- Amgen Inc, CA USA
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(creator_code:org_t)
- Waltham, MA, United States : MASSACHUSETTS MEDICAL SOC, 2021
- 2021
- Engelska.
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Ingår i: New England Journal of Medicine. - Waltham, MA, United States : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 384:2, s. 105-116
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Among patients with heart failure and a reduced ejection fraction, those who received the cardiac myosin activator omecamtiv mecarbil had a lower incidence of a composite of heart-failure events or cardiovascular death at a median of 22 months than those who received placebo. Background The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. Methods We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. Results During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P=0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. Conclusions Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, ; EudraCT number, 2016-002299-28.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Teerlink, John R ...
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Diaz, Rafael
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Felker, G. Micha ...
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McMurray, John J ...
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Metra, Marco
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Solomon, Scott D ...
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visa fler...
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Adams, Kirkwood ...
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Anand, Inder
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Arias-Mendoza, A ...
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Biering-Sorensen ...
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Bohm, Michael
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Bonderman, Diana
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Cleland, John G. ...
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Corbalan, Ramon
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Crespo-Leiro, Ma ...
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Dahlström, Ulf
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Echeverria, Luis ...
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Fang, James C.
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Filippatos, Gera ...
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Fonseca, Candida
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Goncalvesova, Ev ...
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Goudev, Assen R.
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Howlett, Jonatha ...
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Lanfear, David E ...
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Li, Jing
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Lund, Mayanna
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Macdonald, Peter
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Mareev, Viachesl ...
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Momomura, Shin-i ...
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OMeara, Eileen
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Parkhomenko, Ale ...
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Ponikowski, Piot ...
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Ramires, Felix J ...
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Serpytis, Pranas
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Sliwa, Karen
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Spinar, Jindrich
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Suter, Thomas M.
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Tomcsanyi, Janos
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Vandekerckhove, ...
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Vinereanu, Drago ...
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Voors, Adriaan A ...
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Yilmaz, Mehmet B ...
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Zannad, Faiez
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Sharpsten, Lucie
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Legg, Jason C.
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Varin, Claire
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Honarpour, Narim ...
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Abbasi, Siddique ...
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Malik, Fady I.
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Kurtz, Christoph ...
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New England Jour ...
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