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  • Nucci, Anita M.Georgia State Univ, GA 30303 USA (author)

Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-21
  • SPRINGER,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-173475
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173475URI
  • https://doi.org/10.1007/s00125-020-05358-3DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [HD040364, HD042444, HD051997]; Special Statutory Funding Program for Type 1 Diabetes Research by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institutes of Health; Commission of the European Communities (specific RTD programme Quality of Life and Management of Living Resources)European Union (EU) [QLK1-2002-00372]; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR); JDRF InternationalJuvenile Diabetes Research Foundation; Academy of FinlandAcademy of Finland
  • Aims/hypothesis We aimed to evaluate the relationship between childhood growth measures and risk of developing islet autoimmunity (IA) and type 1 diabetes in children with an affected first-degree relative and increased HLA-conferred risk. We hypothesised that being overweight or obese during childhood is associated with a greater risk of IA and type 1 diabetes. Methods Participants in a randomised infant feeding trial (N = 2149) were measured at 12 month intervals for weight and length/height and followed for IA (at least one positive out of insulin autoantibodies, islet antigen-2 autoantibody, GAD autoantibody and zinc transporter 8 autoantibody) and development of type 1 diabetes from birth to 10-14 years. In this secondary analysis, Cox proportional hazard regression models were adjusted for birthweight and length z score, sex, HLA risk, maternal type 1 diabetes, mode of delivery and breastfeeding duration, and stratified by residence region (Australia, Canada, Northern Europe, Southern Europe, Central Europe and the USA). Longitudinal exposures were studied both by time-varying Cox proportional hazard regression and by joint modelling. Multiple testing was considered using family-wise error rate at 0.05. Results In the Trial to Reduce IDDM in the Genetically at Risk (TRIGR) population, 305 (14.2%) developed IA and 172 (8%) developed type 1 diabetes. The proportions of children overweight (including obese) and obese only were 28% and 9% at 10 years, respectively. Annual growth measures were not associated with IA, but being overweight at 2-10 years of life was associated with a twofold increase in the development of type 1 diabetes (HR 2.39; 95% CI 1.46, 3.92; p < 0.001 in time-varying Cox regression), and similarly with joint modelling. Conclusions/interpretation In children at genetic risk of type 1 diabetes, being overweight at 2-10 years of age is associated with increased risk of progression from multiple IA to type 1 diabetes and with development of type 1 diabetes, but not with development of IA. Future studies should assess the impact of weight management strategies on these outcomes. Graphical abstract

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  • Virtanen, Suvi M.Finnish Inst Hlth & Welf, Finland; Tampere Univ, Finland; Tampere Univ, Finland; Tampere Univ Hosp, Finland; Pirkanmaa Hosp Dist, Finland (author)
  • Cuthbertson, DavidUniv S Florida, FL 33620 USA (author)
  • Ludvigsson, JohnnyLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus(Swepub:liu)johlu29 (author)
  • Einberg, UlleTallinn Childrens Hosp, Estonia (author)
  • Huot, CelineCHU Ste Justine, Canada (author)
  • Castano, LuisUniv Basque Country, Spain (author)
  • Aschemeier, BaerbelChildrens & Adolescents Hosp AUF DER BULT, Germany (author)
  • Becker, Dorothy J.Univ Pittsburgh, PA USA; UPMC Childrens Hosp Pittsburgh, PA USA (author)
  • Knip, MikaelUniv Helsinki, Finland; Helsinki Univ Hosp, Finland; Univ Helsinki, Finland; Folkhalsan Res Ctr, Finland; Tampere Univ Hosp, Finland (author)
  • Krischer, Jeffrey P.Univ S Florida, FL 33620 USA (author)
  • Georgia State Univ, GA 30303 USAFinnish Inst Hlth & Welf, Finland; Tampere Univ, Finland; Tampere Univ, Finland; Tampere Univ Hosp, Finland; Pirkanmaa Hosp Dist, Finland (creator_code:org_t)

Related titles

  • In:Diabetologia: SPRINGER64:4, s. 826-8350012-186X1432-0428

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