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Stress-induced esca...
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Barchiesi, RiccardoLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
(author)
Stress-induced escalation of alcohol self-administration, anxiety-like behavior, and elevated amygdala Avp expression in a susceptible subpopulation of rats
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-02-09
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Wiley,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-173908
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173908URI
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https://doi.org/10.1111/adb.13009DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Wallenberg FoundationEuropean Commission [KAW 2018.0322]; Region Ostergotland; Stiftelsen psykiatriska forskningsfonden; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2013-07434]
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Comorbidity between alcohol use and anxiety disorders is associated with more severe symptoms and poorer treatment outcomes than either of the conditions alone. There is a well-known link between stress and the development of these disorders, with post-traumatic stress disorder as a prototypic example. Post-traumatic stress disorder can arise as a consequence of experiencing traumatic events firsthand and also after witnessing them. Here, we used a model of social defeat and witness stress in rats, to study shared mechanisms of stress-induced anxiety-like behavior and escalated alcohol self-administration. Similar to what is observed clinically, we found considerable individual differences in susceptibility and resilience to the stress. Both among defeated and witness rats, we found a subpopulation in which exposure was followed by emergence of increased anxiety-like behavior and escalation of alcohol self-administration. We then profiled gene expression in tissue from the amygdala, a key brain region in the regulation of stress, alcohol use, and anxiety disorders. When comparing "comorbid" and resilient socially defeated rats, we identified a strong upregulation of vasopressin and oxytocin, and this correlated positively with the magnitude of the alcohol self-administration and anxiety-like behavior. A similar trend was observed in comorbid witness rats. Together, our findings provide novel insights into molecular mechanisms underpinning the comorbidity of escalated alcohol self-administration and anxiety-like behavior.
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Chanthongdee, KanatLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Mahidol Univ, Thailand(Swepub:liu)kanch40
(author)
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Domi, EsiLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)esido51
(author)
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Gobbo, FrancescoUniv Edinburgh, Scotland
(author)
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Coppola, AndreaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)andco82
(author)
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Asratian, AnnaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)annas44
(author)
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Toivainen, SanneLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)santo26
(author)
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Holm, LovisaLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)lovho57
(author)
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Augier, GaëlleLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)gaeau73
(author)
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Xu, LiLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Univ Elect Sci & Technol China, Peoples R China(Swepub:liu)lixu00
(author)
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Augier, EricLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)eriau90
(author)
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Heilig, MarkusLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)marhe41
(author)
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Barbier, EstelleLinköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)estba07
(author)
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Linköpings universitetCentrum för social och affektiv neurovetenskap
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In:Addiction Biology: Wiley26:51355-62151369-1600
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Barchiesi, Ricca ...
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Chanthongdee, Ka ...
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Domi, Esi
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Gobbo, Francesco
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Coppola, Andrea
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Asratian, Anna
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Toivainen, Sanne
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Holm, Lovisa
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Augier, Gaëlle
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Xu, Li
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Augier, Eric
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Heilig, Markus
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Barbier, Estelle
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