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- Hagstrom, HannesKarolinska Institutet (author)
Serum levels of endotrophin are associated with nonalcoholic steatohepatitis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-02-08
- Taylor & Francis,2021
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-173911
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173911URI
- https://doi.org/10.1080/00365521.2021.1879249DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:145909199URI
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- Language:English
- Summary in:English
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- Background and aimsThere are no currently available biomarkers that can accurately indicate the presence of non-alcoholic steatohepatitis (NASH). We investigated the association between endotrophin, a cleavage product of collagen type 6α3, and disease severity in patients with non-alcoholic fatty liver disease (NAFLD).MethodsWe measured serum endotrophin levels in 211 patients with NAFLD and nine healthy controls. Liver biopsy data was available for 141 (67%) of the patients. Associations between endotrophin and the presence of NASH and advanced fibrosis were investigated alone and in combination with standard clinical parameters using logistic regression.ResultsA total of 211 patients were enrolled in this study, consisting of 108 (51%) men and 103 (49%) women with a mean age of 55.6 years. 58 (27%) of the patients had advanced fibrosis. Of those with biopsy data, 87 (62%) had NASH. Serum levels of endotrophin were significantly higher in patients with NAFLD than those in healthy controls (37[±12] vs. 17[±7] ng/mL, p<.001). Serum levels of endotrophin were also significantly higher in patients with NASH than in those without NASH (40[±12] vs. 32[±13] ng/mL, p<.001). A model using age, sex, body mass index and levels of alanine aminotransferase (ALT), glucose and endotrophin effectively predicted the presence of NASH in a derivation (AUROC 0.83, 95%CI = 0.74–0.92) and validation cohort (AUROC 0.71, 95%CI = 0.54–0.88). There was no significant association between serum levels of endotrophin and advanced fibrosis.ConclusionsThese data suggest that serum endotrophin could be a valuable biomarker for diagnosing NASH, but not for detecting advanced fibrosis in NAFLD.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
- Nonalcoholic fatty liver disease; metabolic-associated fatty liver disease; NASH; fibrosis; diagnostic test
Added entries (persons, corporate bodies, meetings, titles ...)
- Bu, DaweiUniv Texas Southwestern Med Ctr Dallas, TX USA (author)
- Nasr, PatrikLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)patna19 (author)
- Ekstedt, MattiasLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)matek92 (author)
- Hegmar, HannesKarolinska Univ Hosp, Sweden; Karolinska Inst, Sweden (author)
- Kechagias, StergiosLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)steke00 (author)
- Zhang, NingyanUniv Texas Hlth Sci Ctr Houston, TX 77030 USA (author)
- An, ZhiqiangUniv Texas Hlth Sci Ctr Houston, TX 77030 USA (author)
- Stal, PerKarolinska Institutet (author)
- Scherer, Philipp E.Univ Texas Southwestern Med Ctr Dallas, TX USA; Univ Texas Southwestern Med Ctr Dallas, TX 75390 USA (author)
- Karolinska InstitutetUniv Texas Southwestern Med Ctr Dallas, TX USA (creator_code:org_t)
Related titles
- In:Scandinavian Journal of Gastroenterology: Taylor & Francis56:4, s. 437-4420036-55211502-7708
Internet link
- https://liu.diva-portal.org/smash/get/diva2:1536076/FULLTEXT01.pdffulltext:print
- https://www.tandfonline.com/doi/pdf/10.1080/00365521.2021.1879249?needAccess=true
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173911
- https://doi.org/10.1080/00365521.2021.1879249
- http://kipublications.ki.se/Default.aspx?queryparsed=id:145909199
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