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Calculating the net clinical benefit in neuro-oncology clinical trials using two methods: quality-adjusted survival effect sizes and joint modeling

Coomans, Marijke B. (author)
Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands
Dirven, Linda (author)
Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Haaglanden Medical Center, Den Haag, the Netherlands
Aaronson, Neil K. (author)
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands
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Baumert, Brigitta G. (author)
Institute of Radiation-Oncology, Kantonsspital Graubünden, Chur, Switzerland; Department of Radiation Oncology (MAASTRO clinic), and GROW (School for Oncology and Developmental Biology), Maastricht University Medical Center, Maastricht, the Netherlands
van den Bent, Martin (author)
The Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands
Bottomley, Andrew (author)
Quality of Life Department, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
Brandes, Alba A. (author)
Department of Medical Oncology, Azienda USL-IRCCS Institute of Neurological Sciences, Bologna, Italy
Chinot, Olivier (author)
Aix-Marseille Univ, APHM, CNRS, INP, Inst Neurophysiopathol, CHU Timone, Service de Neuro-Oncologie, Marseille, France
Coens, Corneel (author)
Quality of Life Department, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
Gorlia, Thierry (author)
European Organization for Research and Treatment of Cancer Headquarters, Brussels, Belgium
Herrlinger, Ulrich (author)
Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
Keime-Guibert, Florence (author)
Groupe Hôpital Pitié-Salpetrière, Paris, France
Malmström, Annika (author)
Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Närvårdskliniken
Martinelli, Francesca (author)
Quality of Life Department, European Organisation for Research and Treatment of Cancer, Brussels, Belgium
Sloan, Jeff A (author)
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
Stupp, Roger (author)
Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
Talacchi, Andrea (author)
Department of Neurosciences, Azienda Ospedaliera San Giovanni Addolorata, Roma, Italia
Weller, Michael (author)
Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland
Wick, Wolfgang (author)
Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany
Reijneveld, Jaap C (author)
Department of Neurology and Brain Tumour Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, the Netherlands
Taphoorn, Martin J B (author)
Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Haaglanden Medical Center, Den Haag, the Netherlands
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 (creator_code:org_t)
2020-10-29
2020
English.
In: Neuro-Oncology Advances. - : Oxford University Press. - 2632-2498. ; 2:1
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Two methods combining survival and health-related quality of life (HRQoL) data in glioma trials to calculate the "net clinical benefit" were evaluated: Quality-adjusted effect sizes (QASES) and joint modeling (JM).

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

glioma; joint model; net clinical benefit; quality of life; survival

Publication and Content Type

ref (subject category)
art (subject category)

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