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- Das, Nandan,1983-Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,Natl Univ Ireland, Ireland (author)
Nanoscale structure detection and monitoring of tumour growth with optical coherence tomography
- Article/chapterEnglish2020
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- 2020
- ROYAL SOC CHEMISTRY,2020
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- LIBRIS-ID:oai:DiVA.org:liu-174529
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174529URI
- https://doi.org/10.1039/d0na00371aDOI
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- Language:English
- Summary in:English
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- Funding agencies: Irish Research Council(IRC), under Government of Ireland postdoctoral fellowship with project ID: GOIPD/2017/837; European Union's Horizon 2020 research and innovationprogram under grant agreements no. 761214 and no. 779960; NUI Galway, Galway University Foundation; the University of Limerick Foundation; the National Biophotonics Imaging Platform (NBIP) Ireland funded under the Higher Education Authority PRTLI Cycle 4 and cofunded by the Irish Government and the European Union.
- Approximately 90% of cancers originate in epithelial tissues leading to epithelial thickening, but the ultrastructural changes and underlying architecture are less well known. Depth resolved label free visualization of nanoscale tissue morphology is required to reveal the extent and distribution of ultrastructural changes in underlying tissue, but is difficult to achieve with existing imaging modalities. We developed a nanosensitive optical coherence tomography (nsOCT) approach to provide suchimaging based on dominant axial structure with a few nanometre detection accuracy. nsOCT maps the distribution of axial structural sizes an order of magnitude smaller than the axial resolution of the system. We validated nsOCT methodology by detecting synthetic axial structure via numerical simulations. Subsequently, we validated the nsOCT technique experimentally by detecting known structures from a commercially fabricated sample. nsOCT reveals scaling with different depth of dominant submicronstructural changes associated with carcinoma which may inform the origins of the disease, its progression and improve diagnosis.
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- Sergey, AlexandrovNatl Univ Ireland, Ireland (author)
- Zhou, YiNatl Univ Ireland, Ireland (author)
- Gilligan, Katie E.Natl Univ Ireland Galway, Ireland (author)
- Dwyer, Roisin M.Natl Univ Ireland Galway, Ireland (author)
- Leahy, MartinNatl Univ Ireland, Ireland; Inst Photon Sci ICFO, Spain (author)
- Linköpings universitetAvdelningen för medicinsk teknik (creator_code:org_t)
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- In:Nanoscale Advances: ROYAL SOC CHEMISTRY2:7, s. 2853-28582516-0230
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