Sökning: WFRF:(Linge Jennifer) >
Psoriatic arthritis...
Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity : a cross-sectional study
-
- Ferguson, Lyn D (författare)
- AMRA Medical, Linköping.
-
- Linge, Jennifer (författare)
- Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten,AMRA Medical, Linköping.
-
- Dahlqvist Leinhard, Olof, 1978- (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Medical, Linköping.
-
visa fler...
-
- Woodward, Rosemary (författare)
- Glasgow Clinical Research Imaging Facility, Queen Elizabeth University Hospital.
-
- Hall Barrientos, Pauline (författare)
- Glasgow Clinical Research Imaging Facility, Queen Elizabeth University Hospital.
-
- Roditi, Giles (författare)
- Glasgow Clinical Research Imaging Facility, Queen Elizabeth University Hospital.
-
- Radjenovic, Aleksandra (författare)
- Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
-
- McInnes, Iain B (författare)
- Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK.
-
- Siebert, Stefan (författare)
- Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, UK.
-
- Sattar, Naveed (författare)
- Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
-
visa färre...
-
AMRA Medical, Linköping Avdelningen för samhälle och hälsa (creator_code:org_t)
- 2020-11-04
- 2021
- Engelska.
-
Ingår i: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 60:4, s. 1858-1862
- Relaterad länk:
-
https://liu.diva-por... (primary) (Raw object)
-
visa fler...
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES: To compare body composition in PsA with metabolic disease free (MDF) controls and type 2 diabetes and assess body-composition predicted propensity for cardiometabolic disease.METHODS: Detailed MRI body composition profiles of 26 PsA participants from the IMAPA study were compared with 130 age, sex and BMI-matched MDF controls and 454 individuals with type 2 diabetes from UK Biobank. The body-composition predicted propensity for coronary heart disease (CHD) and type 2 diabetes was compared between PsA and matched MDF controls.RESULTS: PsA participants had a significantly greater visceral adipose tissue (VAT) volume [mean 5.89 l (s.d. 2.10 l)] compared with matched-MDF controls [mean 4.34 l (s.d. 1.83 l)] (P <0.001) and liver fat percentage [median 8.88% (interquartile range 4.42-13.18%)] compared with MDF controls [3.29% (1.98-7.25%)] (P <0.001). These differences remained significant after adjustment for age, sex and BMI. There were no statistically significant differences in VAT, liver fat or muscle fat infiltration (MFI) between PsA and type 2 diabetes. PsA participants had a lower thigh muscle volume than MDF controls and those with type 2 diabetes. Body composition-predicted propensity for CHD and type 2 diabetes was 1.27 and 1.83 times higher, respectively, for PsA compared with matched-MDF controls.CONCLUSION: Individuals with PsA have an adverse body composition phenotype with greater visceral and ectopic liver fat and lower thigh muscle volume than matched MDF controls. Body fat distribution in PsA is more in keeping with the pattern observed in type 2 diabetes and is associated with greater propensity to cardiometabolic disease. These data support the need for greater emphasis on weight loss in PsA management to lessen CHD and type 2 diabetes risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- CHD
- diabetes
- ectopic fat
- obesity
- psoriatic arthritis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas