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Large-scale associa...
Large-scale association analyses identify host factors influencing human gut microbiome composition
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- Kurilshikov, Alexander (author)
- Univ Groningen, Netherlands
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- Medina-Gomez, Carolina (author)
- Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands
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- Bacigalupe, Rodrigo (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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show more...
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- Radjabzadeh, Djawad (author)
- Erasmus MC Univ Med Ctr, Netherlands
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- Wang, Jun (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium; Chinese Acad Sci, Peoples R China
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- Demirkan, Ayse (author)
- Univ Groningen, Netherlands; Univ Surrey, England
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- Le Roy, Caroline I (author)
- Kings Coll London, England
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- Garay, Juan Antonio Raygoza (author)
- Univ Toronto, Canada; Mt Sinai Hosp, Canada
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- Finnicum, Casey T. (author)
- Avera McKennan Hosp, SD USA; Univ Hlth Ctr, SD USA
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- Liu, Xingrong (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden
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- Zhernakova, Daria V (author)
- Univ Groningen, Netherlands; ITMO Univ, Russia
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- Bonder, Marc Jan (author)
- Univ Groningen, Netherlands
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- Hansen, Tue H. (author)
- Univ Copenhagen, Denmark
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- Frost, Fabian (author)
- Univ Med Greifswald, Germany
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- Ruhlemann, Malte C. (author)
- Christian Albrechts Univ Kiel, Germany
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- Turpin, Williams (author)
- Univ Toronto, Canada; Mt Sinai Hosp, Canada
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- Moon, Jee-Young (author)
- Albert Einstein Coll Med, NY 10467 USA
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- Kim, Han-Na (author)
- Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea
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- Lull, Kreete (author)
- Univ Tartu, Estonia
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- Barkan, Elad (author)
- Weizmann Inst Sci, Israel
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- Andreasson, Anna (author)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Copenhagen Univ Hosp, Denmark,Stockholm Univ, Sweden,Univ Bristol, England; Univ Bristol Sch Med, England,Kings Coll London, England; Univ Oxford, England,Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands,Erasmus MC Univ Med Ctr, Netherlands,Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA
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- Fornage, Myriam (author)
- Univ Texas Hlth Sci Ctr Houston, TX 77030 USA
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- Szopinska-Tokov, Joanna (author)
- Univ Texas Hlth Sci Ctr Houston, TX USA; Radboudumc, Netherlands
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- Wallen, Zachary D. (author)
- Univ Alabama Birmingham, AL 35294 USA
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- Borisevich, Dmitrii (author)
- Univ Copenhagen, Denmark
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- Agreus, Lars (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Andreasson, Anna (author)
- Stockholm Univ, Sweden
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- Bang, Corinna (author)
- Christian Albrechts Univ Kiel, Germany
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- Bedrani, Larbi (author)
- Univ Toronto, Canada
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- Bell, Jordana T. (author)
- Kings Coll London, England
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- Bisgaard, Hans (author)
- Copenhagen Univ Hosp, Denmark
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- Boehnke, Michael (author)
- Univ Michigan, MI 48109 USA
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- Boomsma, Dorret I (author)
- Vrije Univ, Netherlands
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- Burk, Robert D. (author)
- Albert Einstein Coll Med, NY 10467 USA
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- Claringbould, Annique (author)
- Univ Groningen, Netherlands
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- Croitoru, Kenneth (author)
- Univ Toronto, Canada; Mt Sinai Hosp, Canada
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- Davies, Gareth E. (author)
- Avera McKennan Hosp, SD USA; Univ Hlth Ctr, SD USA; Vrije Univ, Netherlands
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- van Duijn, Cornelia M. (author)
- Erasmus MC Univ Med Ctr, Netherlands; Univ Oxford, England
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- Duijts, Liesbeth (author)
- Erasmus MC Univ Med Ctr, Netherlands
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- Falony, Gwen (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Fu, Jingyuan (author)
- Univ Groningen, Netherlands
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- van der Graaf, Adriaan (author)
- Univ Groningen, Netherlands
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- Hansen, Torben (author)
- Univ Copenhagen, Denmark
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- Homuth, Georg (author)
- Univ Med Greifswald, Germany
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- Hughes, David A. (author)
- Univ Bristol, England; Univ Bristol Sch Med, England
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- Ijzerman, Richard G. (author)
- Amsterdam Univ Med Ctr, Netherlands
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- Jackson, Matthew A. (author)
- Kings Coll London, England; Univ Oxford, England
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- Jaddoe, Vincent W. V. (author)
- Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands
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- Joossens, Marie (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Jorgensen, Torben (author)
- Univ Copenhagen, Denmark; Univ Copenhagen, Denmark
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- Keszthelyi, Daniel (author)
- Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands
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- Knight, Rob (author)
- Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA
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- Laakso, Markku (author)
- Univ Eastern Finland, Finland
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- Laudes, Matthias (author)
- Univ Hosp Schleswig Holstein, Germany
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- Launer, Lenore J. (author)
- NIA, MD 20892 USA
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- Lieb, Wolfgang (author)
- Univ Kiel, Germany
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- Lusis, Aldons J. (author)
- Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA USA; Univ Calif Los Angeles, CA 90024 USA
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- Masclee, Ad A. M. (author)
- Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands
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- Moll, Henriette A. (author)
- Erasmus MC Univ Med Ctr, Netherlands
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- Mujagic, Zlatan (author)
- Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands
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- Qibin, Qi (author)
- Albert Einstein Coll Med, NY 10467 USA
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- Rothschild, Daphna (author)
- Weizmann Inst Sci, Israel
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- Shin, Hocheol (author)
- Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea
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- Sorensen, Soren J. (author)
- Univ Copenhagen, Denmark
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- Steves, Claire J. (author)
- Kings Coll London, England
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- Thorsen, Jonathan (author)
- Copenhagen Univ Hosp, Denmark
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- Timpson, Nicholas J. (author)
- Univ Bristol, England; Univ Bristol Sch Med, England
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- Tito, Raul Y. (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Vieira-Silva, Sara (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Volker, Uwe (author)
- Univ Med Greifswald, Germany
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- Volzke, Henry (author)
- Univ Med Greifswald, Germany
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- Vosa, Urmo (author)
- Univ Groningen, Netherlands
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- Wade, Kaitlin H. (author)
- Univ Bristol, England; Univ Bristol Sch Med, England
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- Walter, Susanna (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken
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- Watanabe, Kyoko (author)
- Vrije Univ Amsterdam, Netherlands
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- Weiss, Stefan (author)
- Univ Med Greifswald, Germany
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- Weiss, Frank U. (author)
- Univ Med Greifswald, Germany
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- Weissbrod, Omer (author)
- Harvard Univ, MA 02115 USA
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- Westra, Harm-Jan (author)
- Univ Groningen, Netherlands
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- Willemsen, Gonneke (author)
- Vrije Univ, Netherlands
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- Payami, Haydeh (author)
- Univ Alabama Birmingham, AL 35294 USA
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- Jonkers, Daisy M. A. E. (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain
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- Vasquez, Alejandro Arias (author)
- Univ Texas Hlth Sci Ctr Houston, TX USA; Radboudumc, Netherlands; Radboudumc, Netherlands
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- de Geus, Eco J. C. (author)
- Vrije Univ, Netherlands; Amsterdam UMC, Netherlands
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- Meyer, Katie A. (author)
- Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA
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- Stokholm, Jakob (author)
- Copenhagen Univ Hosp, Denmark
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- Segal, Eran (author)
- Weizmann Inst Sci, Israel
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- Org, Elin (author)
- Univ Tartu, Estonia
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- Wijmenga, Cisca (author)
- Univ Groningen, Netherlands
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- Kim, Hyung-Lae (author)
- Ewha Womans Univ, South Korea
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- Kaplan, Robert C. (author)
- Fred Hutchinson Canc Res Ctr, WA USA
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- Spector, Tim D. (author)
- Kings Coll London, England
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- Uitterlinden, Andre G. (author)
- Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands
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- Rivadeneira, Fernando (author)
- Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands
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- Franke, Andre (author)
- Christian Albrechts Univ Kiel, Germany
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- Lerch, Markus M. (author)
- Univ Med Greifswald, Germany
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- Franke, Lude (author)
- Univ Groningen, Netherlands
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- Sanna, Serena (author)
- Univ Groningen, Netherlands; CNR, Italy
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- DAmato, Mauro (author)
- Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain
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- Pedersen, Oluf (author)
- Univ Copenhagen, Denmark
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- Paterson, Andrew D. (author)
- Hosp Sick Children Res Inst, Canada
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- Kraaij, Robert (author)
- Erasmus MC Univ Med Ctr, Netherlands
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- Raes, Jeroen (author)
- Katholieke Univ Leuven, Belgium; VIB, Belgium
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- Zhernakova, Alexandra (author)
- Univ Groningen, Netherlands
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(creator_code:org_t)
- 2021-01-18
- 2021
- English.
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 53:2, s. 156-165
- Related links:
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https://pure.rug.nl/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) < P < 5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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Kurilshikov, Ale ...
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Medina-Gomez, Ca ...
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Bacigalupe, Rodr ...
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Radjabzadeh, Dja ...
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Wang, Jun
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Demirkan, Ayse
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show more...
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Le Roy, Caroline ...
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Garay, Juan Anto ...
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Finnicum, Casey ...
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Liu, Xingrong
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Zhernakova, Dari ...
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Bonder, Marc Jan
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Hansen, Tue H.
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Frost, Fabian
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Ruhlemann, Malte ...
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Turpin, Williams
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Moon, Jee-Young
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Kim, Han-Na
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Lull, Kreete
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Barkan, Elad
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Andreasson, Anna
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Fornage, Myriam
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Szopinska-Tokov, ...
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Wallen, Zachary ...
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Borisevich, Dmit ...
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Agreus, Lars
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Bang, Corinna
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Bedrani, Larbi
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Bell, Jordana T.
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Bisgaard, Hans
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Boehnke, Michael
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Boomsma, Dorret ...
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Burk, Robert D.
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Claringbould, An ...
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Croitoru, Kennet ...
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Davies, Gareth E ...
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van Duijn, Corne ...
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Duijts, Liesbeth
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Falony, Gwen
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Fu, Jingyuan
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van der Graaf, A ...
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Hansen, Torben
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Homuth, Georg
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Hughes, David A.
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Ijzerman, Richar ...
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Jackson, Matthew ...
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Jaddoe, Vincent ...
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Joossens, Marie
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Jorgensen, Torbe ...
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Keszthelyi, Dani ...
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Knight, Rob
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Laakso, Markku
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Laudes, Matthias
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Launer, Lenore J ...
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Lieb, Wolfgang
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Lusis, Aldons J.
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Masclee, Ad A. M ...
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Moll, Henriette ...
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Mujagic, Zlatan
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Qibin, Qi
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Rothschild, Daph ...
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Shin, Hocheol
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Sorensen, Soren ...
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Steves, Claire J ...
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Thorsen, Jonatha ...
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Timpson, Nichola ...
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Tito, Raul Y.
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Vieira-Silva, Sa ...
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Volker, Uwe
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Volzke, Henry
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Vosa, Urmo
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Wade, Kaitlin H.
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Walter, Susanna
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Watanabe, Kyoko
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Weiss, Stefan
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Weiss, Frank U.
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Weissbrod, Omer
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Westra, Harm-Jan
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Willemsen, Gonne ...
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Payami, Haydeh
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Jonkers, Daisy M ...
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Vasquez, Alejand ...
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de Geus, Eco J. ...
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Meyer, Katie A.
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Stokholm, Jakob
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Segal, Eran
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Org, Elin
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Wijmenga, Cisca
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Kim, Hyung-Lae
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Kaplan, Robert C ...
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Spector, Tim D.
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Uitterlinden, An ...
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Rivadeneira, Fer ...
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Franke, Andre
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Lerch, Markus M.
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Franke, Lude
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Sanna, Serena
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DAmato, Mauro
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Pedersen, Oluf
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Paterson, Andrew ...
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Kraaij, Robert
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Raes, Jeroen
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Zhernakova, Alex ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Genetics
- By the university
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Linköping University
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Stockholm University
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Karolinska Institutet