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  • Neira, WaldirDepartment of Ophthalmology, University of Helsinki, Helsinki, Finland (author)

Dystrophia Helsinglandica : corneal morphology, topography and sensitivity in a hereditary corneal disease with recurrent erosive episodes

  • BookEnglish

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  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-17489
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17489URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

Notes

  • Purpose: The aim of this study was to describe the morphology, corneal topography and sensitivity in individuals with Dystrophia Helsinglandica. This autosomal dominant corneal disease is characterized by recurrent corneal erosive episodes and progressive subepithelial fibrosis not significantly affecting visual acuity. Methods: The corneas of nine affected and nine unaffected individuals were examined using slit‐lamp biomicroscopy, in‐vivo confocal microscopy, and videokeratography. Corneal mechanical sensitivity was also measured using a noncontact esthesiometer. Results: Slit‐lamp biomicroscopy revealed that the affected individuals represented different stages of corneal changes, from a nearly normal cornea to subepithelial fibrosis of the central cornea. Corneal changes in affected individuals did not significantly decrease the best spectacle‐corrected visual acuity. In‐vivo confocal microscopy detected morphological changes in the epithelium and stroma. Subepithelial opacity formation including altered keratocytes could be found in the anterior stroma in all affected eyes. With the exception of two eyes (one affected and one unaffected), all videokeratographies showed irregular astigmatism. Corneal sensitivity was significantly lower in affected individuals (p ≤0.01). Age and corneal sensitivity showed no correlation. Conclusion: The main morphological findings in affected individuals were discrete and progressive subepithelial fibrosis, in the in‐vivo confocal microscope corresponding to optically dense extracellular matrix and activated keratocytes. Subbasal nerve morphology was changed in the affected family members who also showed a decreased corneal sensitivity. The findings were per se not specific to the disease. The changes probably reflect a healing response to erosive events on the corneal surface influenced by the genotype.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hammar, BjörnÖstergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM (author)
  • Holopainen, Juha M.Department of Ophthalmology, University of Helsinki, Helsinki, Finland (author)
  • Tuisku, IlpoDepartment of Ophthalmology, University of Helsinki, Helsinki, Finland (author)
  • Dellby, AnetteÖstergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM,Landstinget i Östergötland (author)
  • Tervo, TimoDepartment of Ophthalmology, University of Helsinki, Helsinki, Finland (author)
  • Fagerholm, PerÖstergötlands Läns Landsting,Linköpings universitet,Oftalmiatrik,Hälsouniversitetet,Ögonkliniken US/LiM(Swepub:liu)perfa04 (author)
  • Department of Ophthalmology, University of Helsinki, Helsinki, FinlandOftalmiatrik (creator_code:org_t)

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