Sökning: id:"swepub:oai:DiVA.org:liu-176173" >
Progesterone Dampen...
-
Hellberg, SandraLinköpings universitet,Bioinformatik,Tekniska fakulteten
(författare)
Progesterone Dampens Immune Responses in In Vitro Activated CD4(+) T Cells and Affects Genes Associated With Autoimmune Diseases That Improve During Pregnancy
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
-
2021-05-12
-
Frontiers Media SA,2021
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-176173
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176173URI
-
https://doi.org/10.3389/fimmu.2021.672168DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [SB16-0011]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02776]; Swedish Foundation for MS research; NEURO Sweden; Swedish Society of Medicine [SLS-879791]; Swedish Lions Foundations research funds
-
The changes in progesterone (P4) levels during and after pregnancy coincide with the temporary improvement and worsening of several autoimmune diseases like multiple sclerosis (MS) and rheumatoid arthritis (RA). Most likely immune-endocrine interactions play a major role in these pregnancy-induced effects. In this study, we used next generation sequencing to investigate the direct effects of P4 on CD4(+) T cell activation, key event in pregnancy and disease. We report profound dampening effects of P4 on T cell activation, altering the gene and protein expression profile and reversing many of the changes induced during the activation. The transcriptomic changes induced by P4 were significantly enriched for genes associated with diseases known to be modulated during pregnancy such as MS, RA and psoriasis. STAT1 and STAT3 were significantly downregulated by P4 and their downstream targets were significantly enriched among the disease-associated genes. Several of these genes included well-known and disease-relevant cytokines, such as IL-12 beta, CXCL10 and OSM, which were further validated also at the protein level using proximity extension assay. Our results extend the previous knowledge of P4 as an immune regulatory hormone and support its importance during pregnancy for regulating potentially detrimental immune responses towards the semi-allogenic fetus. Further, our results also point toward a potential role for P4 in the pregnancy-induced disease immunomodulation and highlight the need for further studies evaluating P4 as a future treatment option.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Raffetseder, JohannaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)johra57
(författare)
-
Rundquist, OlofLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)oloru74
(författare)
-
Magnusson, RasmusLinköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten(Swepub:liu)rasma87
(författare)
-
Papapavlou, GeorgiaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)geopa97
(författare)
-
Jenmalm, MariaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marje18
(författare)
-
Ernerudh, JanLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(författare)
-
Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75
(författare)
-
Linköpings universitetBioinformatik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Frontiers in Immunology: Frontiers Media SA121664-3224
Internetlänk
Hitta via bibliotek
Till lärosätets databas