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  • Eap, C. B.Univ Lausanne, Switzerland; Univ Lausanne, Switzerland; Univ Geneva, Switzerland; Univ Geneva, Switzerland; Univ Lausanne, Switzerland (author)

Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests) : focus on antidepressants

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-05-12
  • Taylor & Francis Group,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-176178
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-176178URI
  • https://doi.org/10.1080/15622975.2021.1878427DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146676923URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:for swepub-publicationtype

Notes

  • Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. Methods: This review, which includes more than 500 articles selected by 30 experts, combines relevant knowledge on studies investigating the pharmacokinetics, pharmacodynamics and pharmacogenetics of 33 antidepressant drugs and of 4 drugs approved for augmentation in cases of insufficient response to antidepressant monotherapy. Such studies typically measure drug concentrations in blood (i.e. therapeutic drug monitoring) and genotype relevant genetic polymorphisms of enzymes, transporters or receptors involved in drug metabolism or mechanism of action. Imaging studies, primarily positron emission tomography that relates drug concentrations in blood and radioligand binding, are considered to quantify target structure occupancy by the antidepressant drugs in vivo. Results: Evidence is given that in vivo imaging, therapeutic drug monitoring and genotyping and/or phenotyping of drug metabolising enzymes should be an integral part in the development of any new antidepressant drug. Conclusions: To guide antidepressant drug therapy in everyday practice, there are multiple indications such as uncertain adherence, polypharmacy, nonresponse and/or adverse reactions under therapeutically recommended doses, where therapeutic drug monitoring and cytochrome P450 genotyping and/or phenotyping should be applied as valid tools of precision medicine.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gründer, G.Heidelberg Univ, Germany (author)
  • Baumann, P.Lausanne Univ Hosp, Switzerland; Univ Lausanne, Switzerland (author)
  • Ansermot, N.Univ Lausanne, Switzerland (author)
  • Conca, A.Hlth Serv Dist Bolzano, Italy; S Tyrolean Reg Hlth Serv, Italy (author)
  • Corruble, E.Univ Paris Saclay, France; Hop Bicetre, France (author)
  • Crettol, S.Univ Lausanne, Switzerland (author)
  • Dahl, M. L.Karolinska Institutet (author)
  • de Leon, J.Univ Kentucky, KY USA (author)
  • Greiner, C.Bundesinst Arzneimittel Med Prod, Germany (author)
  • Howes, O.Kings Coll London, England; Imperial Coll, England (author)
  • Kim, E.Seoul Natl Univ, South Korea; Seoul Natl Univ, South Korea (author)
  • Lanzenberger, R.Med Univ Vienna, Austria (author)
  • Meyer, J. H.Univ Toronto, Canada; Univ Toronto, Canada (author)
  • Moessner, R.Univ Tubingen, Germany (author)
  • Mulder, H.Wilhelmina Hosp Assen, Netherlands; GGZ Drenthe Mental Hlth Serv Drenthe, Netherlands; Univ Groningen, Netherlands; Univ Groningen, Netherlands (author)
  • Müller, D. J.Campbell Family Mental Hlth Res Inst, Canada; Univ Toronto, Canada; Univ Toronto, Canada (author)
  • Reis, MargaretaLinköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Skane Univ Hosp, Sweden(Swepub:liu)marre53 (author)
  • Riederer, P.Univ Hosp Wurzburg, Germany; Univ Southern Denmark Odense, Denmark (author)
  • Ruhe, H. G.Radboudumc, Netherlands; Radboud Univ Nijmegen, Netherlands (author)
  • Spigset, O.St Olavs Univ Hosp, Norway; Norwegian Univ Sci, Norway (author)
  • Spina, E.Univ Messina, Italy (author)
  • Stegman, B.Inst Pharm Univ Regensburg, Germany (author)
  • Steimer, W.Syst Univ Munich, Germany (author)
  • Stingl, J.Univ Hosp RWTH Aachen, Germany (author)
  • Suzen, S.Ankara Univ, Turkey (author)
  • Uchida, H.Keio Univ, Japan (author)
  • Unterecker, S.Univ Hosp Wurzburg, Germany (author)
  • Vandenberghe, F.Univ Lausanne, Switzerland (author)
  • Hiemke, C.Univ Med Ctr Mainz, Germany (author)
  • Univ Lausanne, Switzerland; Univ Lausanne, Switzerland; Univ Geneva, Switzerland; Univ Geneva, Switzerland; Univ Lausanne, SwitzerlandHeidelberg Univ, Germany (creator_code:org_t)

Related titles

  • In:World Journal of Biological Psychiatry: Taylor & Francis Group22:8, s. 561-6281562-29751814-1412

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