id:"swepub:oai:DiVA.org:liu-177416"
Search: id:"swepub:oai:DiVA.org:liu-177416" > SARS-CoV-2 rapid an...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Nordgren, JohanLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten (author)
SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- ELSEVIER,2021
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-177416
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177416URI
- https://doi.org/10.1016/j.jcv.2021.104846DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:146893540URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agencies|Region Ostergotland [30320005]
- Background: The COVID-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for SARS-CoV-2 infections that can be used in point of care settings to limit disease transmission. Objective: We evaluated two rapid antigen immunochromatographic tests, Abbott PanbioTM COVID-19 Ag Rapid Test (Panbio) and Zhejiang Orient Gene/Healgen Biotech Coronavirus Ag rapid test cassette (Orient gene) for detection of infectious SARS-CoV-2. Results: The tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or COVID-19 related symptoms, which had been analyzed for SARS-CoV-2 RNA using real-time PCR. In total 156 PCR-positive, and 130 (Panbio) and 176 (Orient Gene) PCR-negative samples were analyzed. Overall sensitivity and specificity were 71.8% and 100% for Panbio and 79.5% and 74.4% for the Orient Gene test respectively. The false positives by the Orient Gene test were verified as SARS-CoV-2 negative by in-house real-time PCR assay and were negative for the four seasonal coronaviruses. Subgroup analysis revealed that the antigen tests had high sensitivity for samples with Ct-values <25 (>88%) and for samples containing infectious viruses as determined by cultivation on Vero cells, 94.1% and 97.1% for the Panbio and Orient gene tests, respectively. Furthermore, both tests had a sensitivity of <50 picogram for nucleocapsid protein. No sample with a Ct-value >27 was shown to contain infectious virus. Conclusion: The results indicate that the rapid antigen tests, especially the Panbio tests may be a valuable tool to detect contagious persons during the ongoing pandemic.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Mikrobiologi inom det medicinska området hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Microbiology in the medical area hsv//eng
- SARS-CoV-2; Rapid antigen test; Infectious virus
Added entries (persons, corporate bodies, meetings, titles ...)
- Sharma, SumitLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)sumsh85 (author)
- Olsson, HenrikNoviral Sweden AB, Sweden (author)
- Jamtberg, MikaelNoviral Sweden AB, Sweden (author)
- Falkeborn, TinaLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Klinisk mikrobiologi(Swepub:liu)tinlu81 (author)
- Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Karolinska Inst, Sweden(Swepub:liu)lensv66 (author)
- Hagbom, MarieLinköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten(Swepub:liu)marha48 (author)
- Linköpings universitetAvdelningen för molekylär medicin och virologi (creator_code:org_t)
Related titles
- In:Journal of Clinical Virology: ELSEVIER1401386-65321873-5967
Internet link
Find in a library
- Journal of Clinical Virology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Nordgren, Johan
- Sharma, Sumit
- Olsson, Henrik
- Jamtberg, Mikael
- Falkeborn, Tina
- Svensson, Lennar ...
- show more...
- Hagbom, Marie
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Microbiology in ...
- Articles in the publication
- Journal of Clini ...
- By the university
- Linköping University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
