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- Amandusson, Åsa,1974-Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet,Klin o experimentell medicin (author)
Estrogen-induced alterations of spinal cord enkephalin gene expression
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- Elsevier,1999
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-17974
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17974URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125109URI
- https://doi.org/10.1016/S0304-3959(99)00109-8DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Enkephalin-synthesizing neurons in the super®cial laminae of the spinal and trigeminal dorsal horn are critical components of the endogenous pain-modulatory system. We have previously demonstrated that these neurons display intracellular estrogen receptors, suggesting that estrogen can potentially influence their enkephalin expression. By using Northern blot, we now show that a bolus injection of estrogen results in a rapid increase in spinal cord enkephalin mRNA levels in ovariectomized female rats. Thus, 4 h after estrogen administration the enkephalin mRNA-expression in the lumbar spinal cord was on average 68% higher (P , 0:05) than in control animals injected with vehicle only. A small increase in the amount of enkephalin mRNA was also seen after 8 h (P , 0:05), whereas no difference between estrogen-injected and control animals was found after 24 h or at time periods shorter than 4 h. Taken together with the previous anatomical data, the present findings imply that estrogen has an acute effect on spinal opioid levels in areas involved in the transmission of nociceptive information.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Preproenkephalin mRNA
- Gonadal hormone
- Pain
- Spinal cord
- MEDICINE
- MEDICIN
- Medical cell biology
- Medical Cell Biology
Added entries (persons, corporate bodies, meetings, titles ...)
- Hallbeck, MartinÖstergötlands Läns Landsting,Linköpings universitet,Experimentell patologi,Hälsouniversitetet,Klinisk patologi och klinisk genetik(Swepub:liu)marha90 (author)
- Hermanson, OlaLinköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet(Swepub:liu)olahe92 (author)
- Blomqvist, AndersLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)andbl47 (author)
- Linköpings universitetInstitutionen för biomedicin och kirurgi (creator_code:org_t)
Related titles
- In:Pain: Elsevier83:2, s. 243-2480304-39591872-6623
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