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  • Zhang, XinLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten (author)

Tailorable Membrane-Penetrating Nanoplatform for Highly Efficient Organelle-Specific Localization

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-06-25
  • Wiley-V C H Verlag GMBH,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-180098
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180098URI
  • https://doi.org/10.1002/smll.202101440DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|STINT Joint China-Sweden Mobility Project [CH2017-7243]; Swedish Research Council (VR)Swedish Research Council [VR 2019-02409, 2020-05437]; China Scholarship Council (CSC)China Scholarship Council; Science and Technology Development Fund, Macau SAR [019/2017/AMJ, 0114/2019/A2]; Carl Tryggers Stiftelse [CTS 19:379]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [Dnr. 5.1-2015-5959]; Centre in Nano Science and technology at LiTH (CeNano); LiU Cancer network at Linkoping University
  • Given the breadth of currently arising opportunities and concerns associated with nanoparticles for biomedical imaging, various types of nanoparticles have been widely exploited, especially for cellular/subcellular level probing. However, most currently reported nanoparticles either have inefficient delivery into cells or lack specificity for intracellular destinations. The absence of well-defined nanoplatforms remains a critical challenge hindering practical nano-based bio-imaging. Herein, the authors elaborate on a tailorable membrane-penetrating nanoplatform as a carrier with encapsulated actives and decorated surfaces to tackle the above-mentioned issues. The tunable contents in such a versatile nanoplatform offer huge flexibility to reach the expected properties and functions. Aggregation-induced emission luminogen (AIEgen) is applied to achieve sought-after photophysical properties, specific targeting moieties are installed to give high affinity towards different desired organelles, and critical grafting of cell-penetrating cyclic disulfides (CPCDs) to promote cellular uptake efficiency without sacrificing the specificity. Hereafter, to validate its practicability, the tailored nano products are successfully applied to track the dynamic correlation between mitochondria and lysosomes during autophagy. The authors believe that the strategy and described materials can facilitate the development of functional nanomaterials for various life science applications.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wang, ChunfeiUniv Macau, Peoples R China; Univ Macau, Peoples R China (author)
  • Feng, GangUniv Macau, Peoples R China; Univ Macau, Peoples R China (author)
  • Jiang, JianxiaLinköpings universitet,Tunnfilmsfysik,Tekniska fakulteten(Swepub:liu)jiaji35 (author)
  • Hu, JiwenLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)jiwhu45 (author)
  • Du Rietz, AnnaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)anndu45 (author)
  • Brommesson, CarolineLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)carsk36 (author)
  • Zhang, XuanjunUniv Macau, Peoples R China; Univ Macau, Peoples R China (author)
  • Ma, YuguangSouth China Univ Technol, Peoples R China (author)
  • Roberg, KarinLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Öron- näsa- och halskliniken(Swepub:liu)karro26 (author)
  • Zhang, FenglingLinköpings universitet,Elektroniska och fotoniska material,Tekniska fakulteten(Swepub:liu)fenzh60 (author)
  • Shen, Han-MingUniv Macau, Peoples R China; Univ Macau, Peoples R China (author)
  • Uvdal, KajsaLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)kajuv09 (author)
  • Hu, Zhang-JunLinköpings universitet,Molekylär ytfysik och nanovetenskap,Tekniska fakulteten(Swepub:liu)zhahu14 (author)
  • Linköpings universitetMolekylär ytfysik och nanovetenskap (creator_code:org_t)

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  • In:Small: Wiley-V C H Verlag GMBH17:311613-68101613-6829

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