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- Eriksson, AndreasLinköpings universitet,Farmakologi,Hälsouniversitetet (författare)
Characterization of static adhesion of human platelets in plasma to protein surfaces in microplates
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
- 2009
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-18037
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18037URI
- https://doi.org/10.1097/MBC.0b013e328327353dDOI
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- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- This is a non-final version of an article published in final form: Andreas Eriksson and Per Whiss , Characterization of static adhesion of human platelets in plasma to protein surfaces in microplates, 2009, BLOOD COAGULATION and FIBRINOLYSIS, (20), 3, 197-206. http://dx.doi.org/10.1097/MBC.0b013e328327353d Copyright: Lippincott Williams and Wilkins; 1999 http://www.lww.com/
- Platelet adhesion is a complex and important event for prevention of blood loss after vessel injury. This study investigated fundamental adhesive mechanisms occurring in an in-vitro assay developed for the measurement of static adhesion of human platelets in plasma. The aim was to gain methodological knowledge that could be used for interpretations of results from other studies using this specific assay. Involvement of adhesive receptors was investigated by the use of various antibodies as well as therapeutic drugs (abciximab, eptifibatide and tirofiban). Inhibitors of adenosine 5-diphosphate receptors (cangrelor, MRS2179) and of thromboxane A(2) signalling (BM-531) were used to estimate the role of autocrine activation. Adhesion to collagen was found to be mainly mediated by alpha(2)beta(1) and to some extent by alpha(IIb)beta(3) Adhesion to fibrinogen was mediated by alpha IIb beta 3. In addition, adenosine 5-diphosphate-induced adhesion to albumin was dependent on alpha(IIb)beta(3). Furthermore, experiments with cangrelor and BM-531 showed that the majority of the adhesive interactions tested were dependent on adenosine 5-diphosphate or thromboxane A(2). We conclude that the mechanisms of adhesion measured by the static platelet adhesion assay are in accordance with the current knowledge regarding platelet activation and adhesion. Despite its simplicity, we suggest that this adhesion assay could be used as a screening device for the study of the influence of various surfaces and soluble substances on platelet adhesion.
Ämnesord och genrebeteckningar
- adhesion receptor
- antiplatelet agents
- autocrine signalling
- platelet adhesion
- platelet assay
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Whiss, PerLinköpings universitet,Farmakologi,Hälsouniversitetet(Swepub:liu)perwh53 (författare)
- Linköpings universitetFarmakologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:BLOOD COAGULATION and FIBRINOLYSIS20:3, s. 197-2060957-5235
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- BLOOD COAGULATION and FIBRINOLYSIS (Sök värdpublikationen i LIBRIS)
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