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- Garvin, PeterLinköpings universitet,Socialmedicin och folkhälsovetenskap,Hälsouniversitetet (författare)
Plasma Levels of Matrix Metalloproteinase-9 are Independently Associated With Psychosocial Factors in a Middle-Aged Normal Population
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
- 2009
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:liu-18140
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18140URI
- https://doi.org/10.1097/PSY.0b013e3181960e7fDOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- This is a non-final version of an article published in final form: Peter Garvin, Lennart Nilsson, John Carstensen, Lena Jonasson and Margareta Kristenson , Plasma Levels of Matrix Metalloproteinase-9 are Independently Associated With Psychosocial Factors in a Middle-Aged Normal Population, 2009, PSYCHOSOMATIC MEDICINE, (71), 3, 292-300. http://dx.doi.org/10.1097/PSY.0b013e3181960e7f Copyright: Lippincott, Williams & Wilkins http://www.lww.com/
- Objective: To test the association between psychosocial factors and circulating levels of matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors have been associated with inflammatory markers and are of prognostic significance for coronary artery disease (CAD). The degrading enzyme MMP-9 is upregulated in inflammatory processes and hypothesized to play a role in the rupture of atherosclerotic plaques. Methods: A total of 402 participants (50% women), aged 45 to 69 years, were drawn randomly from a normal population. Psychosocial instruments covered depression (Center for Epidemiological Studies Depression Questionnaire, CES-D), vital exhaustion, hostile affect, cynicism, mastery, self-esteem, sense of coherence (SOC), emotional support, and social integration. Plasma MMP-9 was measured by an enzyme-linked immunosorbent assay method. Linear regression models were adjusted for age, sex, known CAD, rheumatoid arthritis, cancer, cardiovascular risk factors including C-reactive protein and ongoing medication. Results: After full adjustment, there were independent associations of elevated MMP-9 levels with CES-D (+2.9 ng/ml per SD, p=.02), hostile affect (+3.0 ng/ml per SD, p=.02), cynicism (+3.5 ng/ml per SD, p=.006), and SOC (-2.5 ng/ml per SD, p=.046). A principal component analysis extracted three components. The first was mainly extracted from CES-D, vital exhaustion, self-esteem, mastery, and SOC; the second was mainly extracted from hostile affect and cynicism. Both were independently associated with MMP-9 (p=.02, p=.04) when run in the same model. Conclusions: MMP-9 levels were associated with psychosocial factors in a middle-aged normal population sample, independently of traditional risk factors. The findings may constitute a possible link between psychosocial factors and cardiovascular risk.
Ämnesord och genrebeteckningar
- depression
- hostile affect
- cynicism
- sense of coherence
- metalloproteinases
- cardiovascular
- MEDICINE
- MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Nilsson, LennartÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken(Swepub:liu)lenni29 (författare)
- Carstensen, JohnLinköpings universitet,Hälsa och samhälle,Filosofiska fakulteten(Swepub:liu)johca98 (författare)
- Jonasson, LenaÖstergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken(Swepub:liu)lenjo59 (författare)
- Kristenson, MargaretaLinköpings universitet,Socialmedicin och folkhälsovetenskap,Hälsouniversitetet,Landstinget i Östergötland; Centre for Public Health Sciences; Centre for Public Health Sciences; Folkhälsovetenskapligt centrum; Folkhälsovetenskapligt centrum(Swepub:liu)markr44 (författare)
- Linköpings universitetSocialmedicin och folkhälsovetenskap (creator_code:org_t)
Sammanhörande titlar
- Ingår i:PSYCHOSOMATIC MEDICINE71:3, s. 292-3000033-3174
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