Sökning: onr:"swepub:oai:DiVA.org:liu-182065" >
Association between...
Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta-analysis
-
- Kim, Jong Yeob (författare)
- Yonsei Univ, South Korea
-
- Choi, Min Je (författare)
- Yonsei Univ, South Korea
-
- Ha, Sungji (författare)
- Yonsei Univ, South Korea
-
visa fler...
-
- Hwang, Jimin (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, MD USA
-
- Koyanagi, Ai (författare)
- Univ Barcelona, Spain; ICREA, Spain
-
- Dragioti, Elena (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
-
- Radua, Joaquim (författare)
- Karolinska Institutet
-
- Smith, Lee (författare)
- Anglia Ruskin Univ, England
-
- Jacob, Louis (författare)
- Univ Barcelona, Spain; Univ Versailles St Quentin Yvelines, France
-
- de Pablo, Gonzalo Salazar (författare)
- Kings Coll London, England; South London Maudsley NHS Trust, England; Kings Coll London, England
-
- Lee, Seung Won (författare)
- Sejong Univ Coll Software Convergence, South Korea
-
- Yon, Dong Keon (författare)
- Seoul Natl Univ, South Korea
-
- Thompson, Trevor (författare)
- Univ Greenwich, England; Univ Nottingham, England
-
- Cortese, Samuele (författare)
- Univ Southampton, England; Solent NHS Trust, England; New York Univ Child Study Ctr, NY USA
-
- Lollo, Gianluca (författare)
- Osped Regionale Bellinzona Valli Ente Osped, Switzerland
-
- Liang, Chih-Sung (författare)
- Natl Def Med Ctr, Taiwan; Natl Def Med Ctr, Taiwan
-
- Chu, Che-Sheng (författare)
- Kaohsiung Vet Gen Hosp, Taiwan; Kaohsiung Vet Gen Hosp, Taiwan; Society Psychophysiol, Taiwan; Kaohsiung Med Univ, Taiwan
-
- Fusar-Poli, Paolo (författare)
- Kings Coll London, England; South London & Maudsley NHS Fdn Trust, England; Univ Pavia, Italy; South London & Maudsley NHS Fdn Trust, England
-
- Cheon, Keun-Ah (författare)
- Yonsei Univ, South Korea
-
- Shin, Jae Il (författare)
- Seoul Natl Univ, South Korea
-
- Solmi, Marco (författare)
- Kings Coll London, England; Univ Southampton, England; Univ Ottawa, Canada; Ottawa Hosp, Canada; Univ Ottawa, Canada
-
visa färre...
-
(creator_code:org_t)
- 2021-12-23
- 2022
- Engelska.
-
Ingår i: Autism Research. - : WILEY. - 1939-3792 .- 1939-3806. ; 15:2, s. 340-352
- Relaterad länk:
-
http://gala.gre.ac.u...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Children with autism spectrum disorder (ASD) are frequently diagnosed with co-occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random-effects meta-analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta-regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle-Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25-2.21, p < 0.001; ulcerative colitis, OR = 1.91, 95%CI = 1.41-2.6, p < 0.001; Crohns disease, OR = 1.47, 95%CI = 1.15-1.88, p = 0.002). ASD and IBD were also associated regardless of temporal sequence of diagnosis (any IBD, OR = 1.57, 95%CI = 1.28-1.93, p < 0.001; ulcerative colitis, OR = 1.7, 95%CI = 1.36-2.12, p < 0.001; Crohns disease, OR = 1.37, 95%CI = 1.12-1.69, p = 0.003). Sensitivity analyses confirmed the findings of the main analysis. Meta-regression did not identify any significant moderators. Publication bias was not detected. Quality was high in four datasets and medium in four. In conclusion, our findings highlight the need to screen for IBD in individuals with ASD, and future research should identify who, among those with ASD, has the highest risk of IBD, and elucidate the shared biological mechanisms between ASD and IBD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- autism spectrum disorder; Crohns disease; inflammatory bowel disease; meta-analysis; ulcerative colitis
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kim, Jong Yeob
-
Choi, Min Je
-
Ha, Sungji
-
Hwang, Jimin
-
Koyanagi, Ai
-
Dragioti, Elena
-
visa fler...
-
Radua, Joaquim
-
Smith, Lee
-
Jacob, Louis
-
de Pablo, Gonzal ...
-
Lee, Seung Won
-
Yon, Dong Keon
-
Thompson, Trevor
-
Cortese, Samuele
-
Lollo, Gianluca
-
Liang, Chih-Sung
-
Chu, Che-Sheng
-
Fusar-Poli, Paol ...
-
Cheon, Keun-Ah
-
Shin, Jae Il
-
Solmi, Marco
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Autism Research
- Av lärosätet
-
Linköpings universitet
-
Karolinska Institutet