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Cilostazol-imprinte...
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Yadav, JyotiPolish Acad Sci, Poland
(författare)
Cilostazol-imprinted polymer film-coated electrode as an electrochemical chemosensor for selective determination of cilostazol and its active primary metabolite
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022
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ROYAL SOC CHEMISTRY,2022
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-182075
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182075URI
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https://doi.org/10.1039/d1tb02186aDOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Polish National Science Foundation (NCN) [2015/19/B/ST4/03743]
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An electrochemical chemosensor for cilostazol (CIL) determination was devised, engineered, and tested. For that, a unique conducting film of the functionalized thiophene-appended carbazole-based polymer, molecularly imprinted with cilostazol (MIP-CIL), was potentiodynamically deposited on a Pt disk electrode by oxidative electropolymerization. Thanks to electro-oxidation potentials lower than that of CIL, the carbazole monomers outperformed pyrrole, thiophene, and phenol monomers, in this electropolymerization. The pre-polymerization complexes quantum-mechanical and molecular dynamics analysis allowed selecting the most appropriate monomer from the three thiophene-appended carbazoles examined. The electrode was then used as a selective CIL chemosensor in the linear dynamic concentration range of 50 to 924 nM with a high apparent imprinting factor, IF = 10.6. The MIP-CIL responded similarly to CIL and CILs pharmacologically active primary metabolite, 3,4-dehydrocilostazol (dhCIL), thus proving suitable for their determination together. Simulated models of the MIP cavities binding of the CIL, dhCIL, and interferences molecules allowed predicting chemosensor selectivity. The MIP film sorption of CIL and dhCIL was examined using DPV by peak current data fitting with the Langmuir (L), Freundlich (F), and Langmuir-Freundlich (LF) isotherms. The LF isotherm best described this sorption with the sorption equilibrium constant (K-LF) for CIL and dhCIL of 12.75 x 10(-6) and 0.23 x 10(-6) M, respectively. Moreover, the chemosensor cross-reactivity to common interferences study resulted in the selectivity to cholesterol and dehydroaripiprazole of 1.52 and 8.0, respectively. The chemosensor proved helpful in determining CIL and dhCIL in spiked human plasma with appreciable recovery (99.3-134.1%) and limit of detection (15 nM).
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rybakiewicz, Renata,1985-Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten,Cardinal Stefan Wyszynski Univ Warsaw, Poland(Swepub:liu)renry40
(författare)
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Zolek, TeresaMed Univ Warsaw, Poland
(författare)
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Maciejewska, DorotaMed Univ Warsaw, Poland
(författare)
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Gilant, EdytaInd Chem Inst, Poland
(författare)
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Bus-Kwasnik, KatarzynaInd Chem Inst, Poland
(författare)
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Kutner, AndrzejMed Univ Warsaw, Poland
(författare)
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Noworyta, Krzysztof R.Polish Acad Sci, Poland
(författare)
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Kutner, WlodzimierzPolish Acad Sci, Poland; Cardinal Stefan Wyszynski Univ Warsaw, Poland
(författare)
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Polish Acad Sci, PolandLaboratoriet för organisk elektronik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of materials chemistry. B: ROYAL SOC CHEMISTRY10:35, s. 6707-67152050-750X2050-7518
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