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Effects of antipsyc...
Effects of antipsychotic treatment on cardio-cerebrovascular related mortality in schizophrenia : A subanalysis of a systematic review and meta-analysis with meta-regression of moderators
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- Solmi, Marco (author)
- Department of Psychiatry, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada; Department of Mental Health, The Ottawa Hospital, Ottawa, Canada; Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ottawa, Canada
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- Croatto, Giovanni (author)
- Mental Health Department, AULSS 3 Serenissima, Mestre, Venice, Italy
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- Gupta, Arnav (author)
- Department of Medicine, University of Calgary, Calgary, Canada; College of Public Health, Kent State University, Kent, United States
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- Fabiano, Nicholas (author)
- Department of Psychiatry, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada; SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ottawa, Canada
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- Wong, Stanley (author)
- SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ottawa, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada
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- Fornaro, Michele (author)
- Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Dentistry, Federico II University of Naples, Naples, Italy
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- Schneider, Lynne Kolton (author)
- WebMD Global LLC, London, United Kingdom
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- Rohani-Montez, S. Christy (author)
- WebMD Global LLC, London, United Kingdom
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- Fairley, Leanne (author)
- WebMD Global LLC, London, United Kingdom
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- Smith, Nathalie (author)
- WebMD Global LLC, London, United Kingdom
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- Bitter, István (author)
- Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
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- Gorwood, Philip (author)
- Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neurosciences of Paris (IPNP), Paris, France; GHU Paris Psychiatrie et Neurosciences (CMME, Sainte-Anne Hospital), Paris, France
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- Taipale, Heidi (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; School of Pharmacy, University of Eastern Finland, Kuopio, Finland
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- Tiihonen, Jari (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland
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- Cortese, Samuele (author)
- Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom; Solent NHS Trust, Southampton, United Kingdom; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, NY, United States; DiMePRe-J-Department of Precision and Regenerative Medicine-Jonic Area, University of Bari "Aldo Moro", Bari, Italy
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- Dragioti, Elena (author)
- Pain and Rehabilitation Centre, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Research Laboratory Psychology of Patients, Families, and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece
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- Rietz, Ebba Du (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Nielsen, Rene Ernst (author)
- Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark
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- Firth, Joseph (author)
- Division of Psychology and Mental Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
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- Fusar-Poli, Paolo (author)
- Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom; Outreach and Support in South-London (OASIS) service, South London and Maudlsey (SLaM) NHS Foundation Trust, United Kingdom; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany
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- Hartman, Catharina (author)
- Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
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- Holt, Richard I. G. (author)
- Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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- Høye, Anne (author)
- Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
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- Koyanagi, Ai (author)
- Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain; ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Lehto, Kelli (author)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
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- Lindgren, Peter (author)
- Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden; The Swedish Institute for Health Economics, Lund, Sweden
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- Manchia, Mirko (author)
- Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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- Nordentoft, Merete (author)
- Mental Health Centre Copenhagen, Department of Clinical Medicine, Copenhagen University Hospital, Denmark
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- Skonieczna-Żydecka, Karolina (author)
- Department of Biochemical Science, Pomeranian Medical University in Szczecin, Szczecin 71-460, Poland
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- Stubbs, Brendon (author)
- Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, United Kingdom
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- Vancampfort, Davy (author)
- Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; University Psychiatric Centre KU Leuven, Kortenberg, Leuven, Belgium
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- De Prisco, Michele (author)
- Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
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- Boyer, Laurent (author)
- AP-HM, Aix-Marseille University, School of medicine - La Timone Medical Campus, UR3279: Health Service Research and Quality of Life Center (CEReSS), Marseille, France
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- Vieta, Eduard (author)
- Bipolar and Depressive Disorders Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain
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- Correll, Christoph U. (author)
- Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; Department of Psychiatry, Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, United States; Department of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, United States
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: European Neuropsychopharmacology. - : Elsevier. - 0924-977X .- 1873-7862. ; 88, s. 6-20
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- To further explore the role of different antipsychotic treatments for cardio-cerebrovascular mortality, we performed several subgroup, sensitivity and meta-regression analyses based on a large previous meta-analysis focusing on cohort studies assessing mortality relative risk (RR) for cardio-cerebrovascular disorders in people with schizophrenia, comparing antipsychotic treatment versus no antipsychotic. Quality assessment through the Newcastle-Ottawa Scale (NOS) and publication bias was measured. We meta-analyzed 53 different studies (schizophrenia patients: n = 2,513,359; controls: n = 360,504,484) to highlight the differential effects of antipsychotic treatment regimens on cardio-cerebrovascular-related mortality in incident and prevalent samples of patients with schizophrenia. We found first generation antipsychotics (FGA) to be associated with higher mortality in incident samples of schizophrenia (oral FGA [RR=2.20, 95 %CI=1.29-3.77, k = 1] and any FGA [RR=1.70, 95 %CI=1.20-2.41, k = 1]). Conversely, second generation antipsychotics (SGAs) and clozapine were associated with reduced cardio-cerebrovascular-related mortality, in prevalent samples of schizophrenia. Subgroup analyses with NOS score ≥7 (higher quality) demonstrated a significantly increased cardio-cerebrovascular disorder-related mortality, among those exposed to FGAs vs SGAs. Meta-regression analyses demonstrated a larger association between antipsychotics and decreased risk of mortality with longer follow-up, recent study year, and higher number of adjustment variables. Overall, this subanalysis of a systematic review contributes to the evolving understanding of the complex role of antipsychotic treatment for cardio-cerebrovascular mortality in schizophrenia, paving the way for more targeted interventions and improved patient outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Antipsychotic
- Cardiovascular
- Cerebrovascular
- Meta-analysis
- Mortality
- Schizophrenia
- Systematic review
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Solmi, Marco
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Croatto, Giovann ...
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Gupta, Arnav
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Fabiano, Nichola ...
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Wong, Stanley
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Fornaro, Michele
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show more...
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Schneider, Lynne ...
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Rohani-Montez, S ...
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Fairley, Leanne
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Smith, Nathalie
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Bitter, István
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Gorwood, Philip
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Taipale, Heidi
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Tiihonen, Jari
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Cortese, Samuele
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Dragioti, Elena
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Rietz, Ebba Du
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Nielsen, Rene Er ...
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Firth, Joseph
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Fusar-Poli, Paol ...
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Hartman, Cathari ...
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Holt, Richard I. ...
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Høye, Anne
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Koyanagi, Ai
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Larsson, Henrik, ...
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Lehto, Kelli
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Lindgren, Peter
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Manchia, Mirko
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Nordentoft, Mere ...
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Skonieczna-Żydec ...
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Stubbs, Brendon
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Vancampfort, Dav ...
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De Prisco, Miche ...
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Boyer, Laurent
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Vieta, Eduard
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Correll, Christo ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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European Neurops ...
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Örebro University