Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia: an international multicenter study

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MARC

Fountoulakis, Konstantinos N.Aristotle Univ Thessaloniki, Greece (author)

Gender, age at onset, and duration of being ill as predictors for the long-term course and outcome of schizophrenia : an international multicenter study

Article/chapterEnglish2022

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CAMBRIDGE UNIV PRESS,2022
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LIBRIS-ID:oai:DiVA.org:liu-183079
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183079URI
https://doi.org/10.1017/S1092852921000742DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|NHMRC Senior Principal Research FellowshipNational Health and Medical Research Council of Australia [APP1059660, APP1156072]
Background The aim of the current study was to explore the effect of gender, age at onset, and duration on the long-term course of schizophrenia. Methods Twenty-nine centers from 25 countries representing all continents participated in the study that included 2358 patients aged 37.21 +/- 11.87 years with a DSM-IV or DSM-5 diagnosis of schizophrenia; the Positive and Negative Syndrome Scale as well as relevant clinicodemographic data were gathered. Analysis of variance and analysis of covariance were used, and the methodology corrected for the presence of potentially confounding effects. Results There was a 3-year later age at onset for females (P < .001) and lower rates of negative symptoms (P < .01) and higher depression/anxiety measures (P < .05) at some stages. The age at onset manifested a distribution with a single peak for both genders with a tendency of patients with younger onset having slower advancement through illness stages (P = .001). No significant effects were found concerning duration of illness. Discussion Our results confirmed a later onset and a possibly more benign course and outcome in females. Age at onset manifested a single peak in both genders, and surprisingly, earlier onset was related to a slower progression of the illness. No effect of duration has been detected. These results are partially in accord with the literature, but they also differ as a consequence of the different starting point of our methodology (a novel staging model), which in our opinion precluded the impact of confounding effects. Future research should focus on the therapeutic policy and implications of these results in more representative samples.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Gender; age at onset; duration; long-term course; outcome; schizophrenia

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Dragioti, ElenaLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)eledr71 (author)
Theofilidis, Antonis T.Aristotle Univ Thessaloniki, Greece (author)
Wiklund, TobiasLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)tobwi28 (author)
Atmatzidis, XenofonLinköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Karolinska Huddinge Univ Hosp, Sweden(Swepub:liu)n/a (author)
Nimatoudis, IoannisAristotle Univ Thessaloniki, Greece (author)
Thys, ErikKatholieke Univ Leuven, Belgium (author)
Wampers, MartienKatholieke Univ Leuven, Belgium; Katholieke Univ Leuven, Belgium (author)
Hranov, LuchezarUniv Multiprofile Hosp, Bulgaria (author)
Hristova, TrayanaUniv Multiprofile Hosp, Bulgaria (author)
Aptalidis, DaniilUniv Multiprofile Hosp, Bulgaria (author)
Milev, RoumenQueens Univ, Canada (author)
Iftene, FeliciaQueens Univ, Canada (author)
Spaniel, FilipNatl Inst Mental Hlth, Czech Republic (author)
Knytl, PavelNatl Inst Mental Hlth, Czech Republic (author)
Furstova, PetraNatl Inst Mental Hlth, Czech Republic (author)
From, TiinaUniv Turku, Finland (author)
Karlsson, HenryUniv Turku, Finland (author)
Walta, MaijaUniv Turku, Finland (author)
Salokangas, Raimo K. R.Univ Turku, Finland (author)
Azorin, Jean-MichelSainte Marguerite Univ Hosp, France; Timone Inst Neurosci, France (author)
Bouniard, JustineSainte Marguerite Univ Hosp, France; Timone Inst Neurosci, France (author)
Montant, JulieSainte Marguerite Univ Hosp, France; Timone Inst Neurosci, France (author)
Juckel, GeorgRuhr Univ Bochum, Germany (author)
Haussleiter, Ida S.Ruhr Univ Bochum, Germany (author)
Douzenis, AthanasiosNatl & Kapodistrian Univ Athens, Greece (author)
Michopoulos, IoannisNatl & Kapodistrian Univ Athens, Greece (author)
Ferentinos, PanagiotisNatl & Kapodistrian Univ Athens, Greece (author)
Smyrnis, NikolaosNatl & Kapodistrian Univ Athens, Greece (author)
Mantonakis, LeonidasNatl & Kapodistrian Univ Athens, Greece (author)
Nemes, ZsofiaNyiro Gyula Hosp, Hungary (author)
Gonda, XeniaSemmelweis Univ, Hungary (author)
Vajda, DoraSemmelweis Univ, Hungary (author)
Juhasz, AnitaSemmelweis Univ, Hungary (author)
Shrivastava, AmreshWestern Univ, Canada (author)
Waddington, JohnRoyal Coll Surgeons Ireland, Ireland (author)
Pompili, MaurizioSapienza Univ Rome, Italy (author)
Comparelli, AnnaSapienza Univ Rome, Italy (author)
Corigliano, ValentinaSapienza Univ Rome, Italy (author)
Rancans, ElmarsRiga Stradins Univ, Latvia (author)
Navickas, AlvydasVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Hilbig, JanVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Bukelskis, LaurynasVilnius Univ, Lithuania; Vilnius Mental Hlth Ctr, Lithuania; Vilnius Mental Hlth Ctr, Lithuania (author)
Stevovic, Lidija I.Clin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro (author)
Vodopic, SanjaClin Ctr Montenegro, Montenegro; Univ Montenegro, Montenegro; Clin Ctr Montenegro, Montenegro (author)
Esan, OluyomiUniv Ibadan, Nigeria (author)
Oladele, OluremiUniv Ibadan, Nigeria (author)
Osunbote, ChristopherUniv Ibadan, Nigeria (author)
Rybakowski, Janusz K.Poznan Univ Med Sci, Poland (author)
Wojciak, PawelPoznan Univ Med Sci, Poland (author)
Domowicz, KlaudiaPoznan Univ Med Sci, Poland (author)
Figueira, Maria L.Santa Maria Univ Hosp, Portugal (author)
Linhares, LudgeroSanta Maria Univ Hosp, Portugal (author)
Crawford, JoanaSanta Maria Univ Hosp, Portugal (author)
Panfil, Anca-LiviaUniv Med & Pharm Targu Mures, Romania (author)
Smirnova, DariaSamara State Med Univ, Russia (author)
Izmailova, OlgaSamara State Med Univ, Russia (author)
Lecic-Tosevski, DusicaInst Mental Hlth, Serbia; Serbian Acad Arts & Sci, Serbia (author)
Temmingh, HenkUniv Cape Town, South Africa (author)
Howells, FleurUniv Cape Town, South Africa (author)
Bobes, JulioUniv Oviedo, Spain; Univ Oviedo, Spain (author)
Garcia-Portilla, Maria P.Univ Oviedo, Spain; Univ Oviedo, Spain (author)
Garcia-Alvarez, LeticiaUniv Oviedo, Spain; Univ Oviedo, Spain (author)
Erzin, GamzeDiskapi Yildirim Beyazit Training & Res Hosp, Turkey (author)
Karadag, HasanDiskapi Yildirim Beyazit Training & Res Hosp, Turkey (author)
De Sousa, AvinashLokmanya Tilak Municipal Gen Hosp & Med Coll, India (author)
Bendre, AnujaLokmanya Tilak Municipal Gen Hosp & Med Coll, India (author)
Hoschl, CyrilNatl Inst Mental Hlth, Czech Republic (author)
Bredicean, CristinaUniv Med & Farm Timisoara, Romania (author)
Papava, IonUniv Med & Farm Timisoara, Romania (author)
Vukovic, OliveraUniv Belgrade, Serbia (author)
Pejuskovic, BojanaBeaumont Hosp, Ireland (author)
Russell, VincentBeaumont Hosp, Ireland (author)
Athanasiadis, LoukasAristotle Univ Thessaloniki, Greece (author)
Konsta, AnastasiaAristotle Univ Thessaloniki, Greece (author)
Fountoulakis, Nikolaos K.Med Univ, Bulgaria (author)
Stein, DanUniv Cape Town, South Africa (author)
Berk, MichaelDeakin Univ, Australia; Natl Ctr Excellence Youth Mental Hlth, Australia; Florey Inst Neurosci & Mental Hlth, Australia; Univ Melbourne, Australia (author)
Dean, OliviaDeakin Univ, Australia; Natl Ctr Excellence Youth Mental Hlth, Australia; Florey Inst Neurosci & Mental Hlth, Australia; Univ Melbourne, Australia (author)
Tandon, RajivUniv Florida, FL USA (author)
Kasper, SiegfriedMed Univ Vienna, Austria (author)
De Hert, MarcKatholieke Univ Leuven, Belgium; Katholieke Univ Leuven, Belgium; AHLEC Univ, Belgium (author)
Aristotle Univ Thessaloniki, GreeceAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

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In:CNS Spectrums: CAMBRIDGE UNIV PRESS27:6, s. 716-7231092-85292165-6509

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By the author/editor: Fountoulakis, Ko ...; Dragioti, Elena; Theofilidis, Ant ...; Wiklund, Tobias; Atmatzidis, Xeno ...; Nimatoudis, Ioan ...; show more...; Thys, Erik; Wampers, Martien; Hranov, Luchezar; Hristova, Trayan ...; Aptalidis, Danii ...; Milev, Roumen; Iftene, Felicia; Spaniel, Filip; Knytl, Pavel; Furstova, Petra; From, Tiina; Karlsson, Henry; Walta, Maija; Salokangas, Raim ...; Azorin, Jean-Mic ...; Bouniard, Justin ...; Montant, Julie; Juckel, Georg; Haussleiter, Ida ...; Douzenis, Athana ...; Michopoulos, Ioa ...; Ferentinos, Pana ...; Smyrnis, Nikolao ...; Mantonakis, Leon ...; Nemes, Zsofia; Gonda, Xenia; Vajda, Dora; Juhasz, Anita; Shrivastava, Amr ...; Waddington, John; Pompili, Maurizi ...; Comparelli, Anna; Corigliano, Vale ...; Rancans, Elmars; Navickas, Alvyda ...; Hilbig, Jan; Bukelskis, Laury ...; Stevovic, Lidija ...; Vodopic, Sanja; Esan, Oluyomi; Oladele, Oluremi; Osunbote, Christ ...; Rybakowski, Janu ...; Wojciak, Pawel; Domowicz, Klaudi ...; Figueira, Maria ...; Linhares, Ludger ...; Crawford, Joana; Panfil, Anca-Liv ...; Smirnova, Daria; Izmailova, Olga; Lecic-Tosevski, ...; Temmingh, Henk; Howells, Fleur; Bobes, Julio; Garcia-Portilla, ...; Garcia-Alvarez, ...; Erzin, Gamze; Karadag, Hasan; De Sousa, Avinas ...; Bendre, Anuja; Hoschl, Cyril; Bredicean, Crist ...; Papava, Ion; Vukovic, Olivera; Pejuskovic, Boja ...; Russell, Vincent; Athanasiadis, Lo ...; Konsta, Anastasi ...; Fountoulakis, Ni ...; Stein, Dan; Berk, Michael; Dean, Olivia; Tandon, Rajiv; Kasper, Siegfrie ...; De Hert, Marc; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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