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Radiotherapy Versus...
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Oonk, Maaike H. M.Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
(author)
Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node : Results of GROINSS-V II
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Lippincott, Williams & Wilkins,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-183263
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183263URI
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https://doi.org/10.1200/JCO.21.00006DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469225URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Dutch Cancer Society (KWF Kankerbestrijding)KWF Kankerbestrijding; NRG Oncology
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PURPOSE The Groningen International Study on Sentinel nodes in Vulvar cancer (GROINSS-V)-II investigated whether inguinofemoral radiotherapy is a safe alternative to inguinofemoral lymphadenectomy (IFL) in vulvar cancer patients with a metastatic sentinel node (SN). METHODS GROINSS-V-II was a prospective multicenter phase-II single-arm treatment trial, including patients with early-stage vulvar cancer (diameter < 4 cm) without signs of lymph node involvement at imaging, who had primary surgical treatment (local excision with SN biopsy). Where the SN was involved (metastasis of any size), inguinofemoral radiotherapy was given (50 Gy). The primary end point was isolated groin recurrence rate at 24 months. Stopping rules were defined for the occurrence of groin recurrences. RESULTS From December 2005 until October 2016, 1,535 eligible patients were registered. The SN showed metastasis in 322 (21.0%) patients. In June 2010, with 91 SN-positive patients included, the stopping rule was activated because the isolated groin recurrence rate in this group went above our predefined threshold. Among 10 patients with an isolated groin recurrence, nine had SN metastases > 2 mm and/or extracapsular spread. The protocol was amended so that those with SN macrometastases (> 2 mm) underwent standard of care (IFL), whereas patients with SN micrometastases (<= 2 mm) continued to receive inguinofemoral radiotherapy. Among 160 patients with SN micrometastases, 126 received inguinofemoral radiotherapy, with an ipsilateral isolated groin recurrence rate at 2 years of 1.6%. Among 162 patients with SN macrometastases, the isolated groin recurrence rate at 2 years was 22% in those who underwent radiotherapy, and 6.9% in those who underwent IFL (P = .011). Treatment-related morbidity after radiotherapy was less frequent compared with IFL. CONCLUSION Inguinofemoral radiotherapy is a safe alternative for IFL in patients with SN micrometastases, with minimal morbidity. For patients with SN macrometastasis, radiotherapy with a total dose of 50 Gy resulted in more isolated groin recurrences compared with IFL.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Slomovitz, BrianMt Sinai Med Ctr, Miami Beach, FL 33140 USA.
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Baldwin, Peter J. W.Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England.
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van Doorn, Helena C.Univ Med Ctr Rotterdam, Erasmus MC Canc Inst, Rotterdam, Netherlands.
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van der Velden, JacobusAmsterdam Univ Med Ctr, Amsterdam, Netherlands.
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de Hullu, Joanne A.Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands.
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Gaarenstroom, Katja N.Leiden Univ Med Ctr, Leiden, Netherlands.
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Slangen, Brigitte F. M.Maastricht Univ Med Ctr, Maastricht, Netherlands.
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Vergote, IgnaceLeuven Canc Inst, Leuven, Belgium.
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Brannstrom, MatsUniv Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
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van Dorst, Eleonora B. L.Univ Med Ctr Utrecht, Utrecht, Netherlands.,Catharina Ziekenhuis Eindhoven, Catharina Ziekenhuis Ein, Netherlands.,Univ N Carolina, Chapel Hill, NC USA.
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van Driel, Willemien J.Netherlands Canc Inst, Ctr Gynecol Oncol Amsterdam, Amsterdam, Netherlands.
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Hermans, Ralph H.Catharina Ziekenhuis Eindhoven, Catharina Ziekenhuis Ein, Netherlands.
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Nunns, DavidNottingham Univ Hosp NHS Trust, Nottingham, England.
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Widschwendter, MartinUCL, UCL EGA Inst Womens Hlth, London, England.
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Nugent, DavidLeeds Teaching Hosp NHS Trust, St James Univ Hosp, Leeds, W Yorkshire, England.
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Holland, Cathrine M.Manchester Univ NHS Fdn Trust, St Marys Hosp, Manchester, Lancs, England.
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Sharma, AartiUniv Hosp Wales, Cardiff, Wales.
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DiSilvestro, Paul A.Women & Infants Hosp Rhode Isl, Providence, RI 02908 USA.
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Mannel, RobertUniv Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK USA.
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Boll, DorryCatharina Ziekenhuis Eindhoven, Netherlands
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Cibula, DavidCharles Univ Prague, Fac Med 1, Prague, Czech Republic.;Gen Univ Hosp Prague, Prague, Czech Republic.
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Covens, AlUniv Toronto, Toronto, ON, Canada.
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Provencher, DianeUniv Montreal, CHUM, Montreal, PQ, Canada.
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Runnebaum, Ingo B.Friedrich Schiller Univ, Jena Univ Hosp, Jena, Germany.
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Luesley, DavidUniv Birmingham, Birmingham, W Midlands, England.
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Ellis, PatriciaRoyal Surrey NHS Fdn Trust, Guildford, Surrey, England.
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Duncan, Timothy J.Norfolk & Norwich Univ Hosp NHS Trust, Norwich, Norfolk, England.
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Tjiong, Ming Y.Amsterdam Univ Med Ctr, Amsterdam, Netherlands.
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Cruickshank, Derek J.South Tees NHS Fdn Trust, James Cook Univ Hosp, Middlesbrough, Cleveland, England.
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Kjölhede, PrebenLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US,Linköping Univ, Linköping, Sweden.(Swepub:liu)prekj14
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Levenback, Charles F.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
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Bouda, JiriCharles Univ Prague, Univ Hosp Pilsen, Fac Med, Plzen, Czech Republic.
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Kieser, Katharina E.Dalhousie Univ, Halifax, NS, Canada.
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Palle, ConnieCapio, Hellerup, Denmark.
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Spirtos, Nicola M.Womens Canc Ctr Nevada, Las Vegas, NV USA.
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OMalley, David M.Ohio State Univ, Comprehens Canc Ctr, James Canc Hosp, Columbus, OH 43210 USA.
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Leitao, Mario M.Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
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Geller, Melissa A.Univ Minnesota, Minneapolis, MN USA.
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Dhar, KalyanSingleton Hosp, Swansea, W Glam, Wales.
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Asher, VirenUniv Hosp Derby & Burton, Derby, England.
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Tamussino, KarlMed Univ Graz, Graz, Austria.
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Tobias, Daniel H.Morristown Med Ctr, Morristown, NJ USA.
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Borgfeldt, ChristerLund Univ, Skane Univ Hosp, Lund, Sweden.
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Lea, Jayanthi S.UT Southwestern Med Ctr, Dallas, TX USA.
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Bailey, JoSt Michaels Hosp, Bristol, Avon, England.,St Josephs Hosp, Phoenix, AZ USA.
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Lood, MargaretaCent Hosp Karlstad, Karlstad, Sweden.
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Eyjolfsdottir, BrynhildurOslo Univ Hosp, Radiumhosp, Oslo, Norway.
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Attard-Montalto, StephenMaidstone Hlth Author, West Kent Canc Ctr, Maidstone, Kent, England.
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Tewari, Krishnansu S.UC Irvine Hlth Med Ctr, Orange, CA USA.
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Manchanda, RanjitQueen Mary Univ London, Wolfson Inst Populat Hlth, London, England.
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Jensen, Pernille T.Aarhus Univ Hosp, Aarhus, Denmark.
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Persson, ParUppsala universitet,Institutionen för kvinnors och barns hälsa,Uppsala Univ, Sweden
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Van Le, LindaUniv N Carolina, NC USA
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Putter, HeinLeiden Univ Med Ctr, Leiden, Netherlands.
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de Bock, Geertruida H.Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
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Monk, Bradley J.St Josephs Hosp, AZ USA
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Creutzberg, Carien L.Leiden Univ Med Ctr, Leiden, Netherlands.
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van der Zee, Ate G. J.Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
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Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.Mt Sinai Med Ctr, Miami Beach, FL 33140 USA.
(creator_code:org_t)
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In:Journal of Clinical Oncology: Lippincott, Williams & Wilkins39:32, s. 3623-36320732-183X1527-7755
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Oonk, Maaike H. ...
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Slomovitz, Brian
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Baldwin, Peter J ...
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van Doorn, Helen ...
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van der Velden, ...
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de Hullu, Joanne ...
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Gaarenstroom, Ka ...
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Slangen, Brigitt ...
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Vergote, Ignace
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Brannstrom, Mats
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van Dorst, Eleon ...
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van Driel, Wille ...
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Hermans, Ralph H ...
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Nunns, David
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Widschwendter, M ...
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Nugent, David
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Holland, Cathrin ...
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Sharma, Aarti
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DiSilvestro, Pau ...
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Mannel, Robert
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Boll, Dorry
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Cibula, David
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Covens, Al
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Provencher, Dian ...
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Runnebaum, Ingo ...
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Luesley, David
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Ellis, Patricia
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Duncan, Timothy ...
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Tjiong, Ming Y.
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Cruickshank, Der ...
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Kjölhede, Preben
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Levenback, Charl ...
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Bouda, Jiri
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Kieser, Katharin ...
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Palle, Connie
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Spirtos, Nicola ...
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OMalley, David M ...
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Leitao, Mario M.
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Geller, Melissa ...
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Dhar, Kalyan
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Asher, Viren
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Tamussino, Karl
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Tobias, Daniel H ...
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Borgfeldt, Chris ...
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Lea, Jayanthi S.
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Bailey, Jo
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Lood, Margareta
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Eyjolfsdottir, B ...
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Attard-Montalto, ...
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Tewari, Krishnan ...
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Manchanda, Ranji ...
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Jensen, Pernille ...
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Persson, Par
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Van Le, Linda
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Putter, Hein
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de Bock, Geertru ...
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Monk, Bradley J.
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