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  • Takamiya, AkihiroKeio Univ, Japan; Katholieke Univ Leuven, Belgium (author)

Neural Substrates of Psychotic Depression : Findings From the Global ECT-MRI Research Collaboration

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-10-08
  • Oxford University Press,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-183602
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183602URI
  • https://doi.org/10.1093/schbul/sbab122DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Keio University Medical Science Fund [99-095-0007]; AMED [JP20dm0307102h0003]; Research Foundation Flanders (FWO) grantFWO [G0C0319N]; KU Leuven Fund [C24/18/095]; Sequoia Fund for Research on Ageing and Mental Health; National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [MH125126, MH111826]; Carlos III Health InstituteInstituto de Salud Carlos III [CD20/00189]; Lundbeck FoundationLundbeckfonden; Western Norway Regional Health Authority [911986, 912238]
  • Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.

Subject headings and genre

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  • Dols, AnnemiekGGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • Emsell, LouiseKatholieke Univ Leuven, Belgium (author)
  • Abbott, ChristopherUniv New Mexico, NM 87131 USA (author)
  • Yrondi, AntoineUniv Toulouse, France (author)
  • Mas, Carles SorianoBellvitge Biomed Res Inst IDIBELL, Spain; Carlos III Hlth Inst, Spain; Univ Autonoma Barcelona, Spain (author)
  • Jorgensen, Martin BalslevPsychiat Ctr Copenhagen, Denmark; Univ Copenhagen, Denmark (author)
  • Nordanskog, Pia,1971-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping(Swepub:liu)piano33 (author)
  • Rhebergen, DidiGGZ Centraal, Netherlands (author)
  • van Exel, EricGGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • Oudega, Mardien L.GGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (author)
  • Bouckaert, FilipKatholieke Univ Leuven, Belgium (author)
  • Vandenbulcke, MathieuKatholieke Univ Leuven, Belgium (author)
  • Sienaert, PascalKatholieke Univ Leuven, Belgium (author)
  • Peran, PatriceUniv Toulouse, France (author)
  • Cano, MartaCarlos III Hlth Inst, Spain; Univ Autonoma Barcelona, Spain; Parc Tauli Univ Hosp, Spain (author)
  • Cardoner, NarcisParc Tauli Univ Hosp, Spain (author)
  • Jorgensen, AndersPsychiat Ctr Copenhagen, Denmark; Univ Copenhagen, Denmark (author)
  • Paulson, Olaf B.Rigshosp, Denmark (author)
  • Hamilton, Paul J.,1970-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)pauha77 (author)
  • Kämpe, Robin,1989-Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten(Swepub:liu)robka95 (author)
  • Bruin, WillemAmsterdam UMC, Netherlands (author)
  • Bartsch, HaukeHaukeland Hosp, Norway; Haukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Ousdal, Olga ThereseHaukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Kessler, UteUniv Bergen, Norway; Haukeland Hosp, Norway (author)
  • van Wingen, GuidoAmsterdam UMC, Netherlands (author)
  • Oltedal, LeifHaukeland Hosp, Norway; Univ Bergen, Norway (author)
  • Kishimoto, TaishiroKeio Univ, Japan (author)
  • Keio Univ, Japan; Katholieke Univ Leuven, BelgiumGGZ InGeest Specialized Mental Hlth Care, Netherlands; Vrije Univ Amsterdam, Netherlands (creator_code:org_t)

Related titles

  • In:Schizophrenia Bulletin: Oxford University Press48:2, s. 514-5230586-76141745-1701

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