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Sarcopenia predicts...
Sarcopenia predicts reduced liver growth and reduced resectability in patients undergoing portal vein embolization before liver resection-A DRAGON collaborative analysis of 306 patients
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- Heil, Jan (author)
- Univ Zurich, Switzerland; Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Gen Visceral & Transplant Surg, Frankfurt, Germany
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- Heid, Franziska (author)
- Univ Zurich, Switzerland; Cantonal Hosp Winterthur, Switzerland
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- Bechstein, Wolf O. (author)
- Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Gen Visceral & Transplant Surg, Frankfurt, Germany
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- Björnsson, Bergthor (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Brismar, Torkel B. (author)
- Karolinska Inst, Sweden
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- Carling, Ulrik (author)
- Oslo Univ Hosp, Norway
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- Erdmann, Joris (author)
- Univ Amsterdam, Netherlands
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- Fretland, Asmund A. (author)
- Oslo Univ Hosp, Norway; Oslo Univ Hosp, Norway
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- Grunhagen, Dirk (author)
- Erasmus Univ, Netherlands
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- Hana, Renato A. (author)
- McGill Gen Hosp, Canada
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- Hohmann, Joachim (author)
- Cantonal Hosp Winterthur, Switzerland; Univ Basel, Switzerland
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- Linke, Richard (author)
- Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Gen Visceral & Transplant Surg, Frankfurt, Germany
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- Meyer, Yannick (author)
- Erasmus Univ, Netherlands
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- Nawawi, Abrar (author)
- McGill Hlth Ctr Res Inst, Canada
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- Olthof, Pim B. (author)
- Univ Amsterdam, Netherlands; Erasmus Univ, Netherlands
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- Sandström, Per (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Schnitzbauer, Andreas A. (author)
- Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Gen Visceral & Transplant Surg, Frankfurt, Germany
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- Sparrelid, Ernesto (author)
- Karolinska Institutet
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- Verhoef, Cornelis (author)
- Erasmus Univ, Netherlands
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- Metrakos, Peter (author)
- Department of Surgery, McGill Health Center Research Institute, Cancer Program, Montreal, Canada
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- Schadde, Erik (author)
- Univ Zurich, Switzerland; Rush Univ, IL USA
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2022
- 2022
- English.
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In: HPB. - : ELSEVIER SCI LTD. - 1365-182X .- 1477-2574. ; 24:3, s. 413-421
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: After portal vein embolization (PVE) 30% fail to achieve liver resection. Malnutrition is a modifiable risk factor and can be assessed by radiological indices. This study investigates, if sarcopenia affects resectability and kinetic growth rate (KGR) after PVE. Methods: A retrospective study was performed of the outcome of PVE at 8 centres of the DRAGON collaborative from 2010 to 2019. All malignant tumour types were included. Sarcopenia was defined using gender, body mass and skeletal muscle index. First imaging after PVE was used for liver volumetry. Primary and secondary endpoints were resectability and KGR. Risk factors impacting liver growth were assessed in a multivariable analysis. Results: Eight centres identified 368 patients undergoing PVE. 62 patients (17%) had to be excluded due to unavailability of data. Among the 306 included patients, 112 (37%) were non-sarcopenic and 194 (63%) were sarcopenic. Sarcopenic patients had a 21% lower resectability rate (87% vs. 66%, p < 0.001) and a 23% reduced KGR (p = 0.02) after PVE. In a multivariable model dichotomized for KGR >2.3% standardized FLR (sFLR)/week, only sarcopenia and sFLR before embolization correlated with KGR. Conclusion: In this largest study of risk factors, sarcopenia was associated with reduced resectability and KGR in patients undergoing PVE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Heil, Jan
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Heid, Franziska
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Bechstein, Wolf ...
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Björnsson, Bergt ...
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Brismar, Torkel ...
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Carling, Ulrik
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Erdmann, Joris
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Fretland, Asmund ...
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Grunhagen, Dirk
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Hana, Renato A.
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Hohmann, Joachim
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Linke, Richard
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Meyer, Yannick
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Nawawi, Abrar
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Olthof, Pim B.
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Sandström, Per
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Schnitzbauer, An ...
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Sparrelid, Ernes ...
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Verhoef, Corneli ...
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Metrakos, Peter
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Schadde, Erik
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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HPB
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Linköping University
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Karolinska Institutet