Role of Tumor Specific niche in Colon Cancer Progression and Emerging Therapies by Targeting Tumor Microenvironment

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Banerjee, AntaraFaculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, India (author)

Role of Tumor Specific niche in Colon Cancer Progression and Emerging Therapies by Targeting Tumor Microenvironment

Article/chapterEnglish2021

Publisher, publication year, extent ...

2019-04-11
Cham :Springer,2021
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-183838
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183838URI
https://doi.org/10.1007/5584_2019_355DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:kap swepub-publicationtype

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Colorectal cancer is the third most common form of cancer worldwide leading to escalating mortality rates and mainly includes hereditary, sporadic and colitis-associated cancer development. The escalated mortality rates is due to the limited treatment options as this form of cancer is usually not easy to diagnose in its early stages and are highly invasive leading to rapid metastasis of the malignant cells to the neighbouring tissue. In order to combat this limitation several chemotherapeutic regimens are now being combined with targeted therapies after the knowledge acquired on the inevitable effects of the tumor microenvironment on the colon cancer growth and progress. The colon tumor niche mainly consists of a large mass of tumor cells along with various immune cells, inflammatory cells, tumor macrophages and fibroblasts that infiltrate the tumor as it is a site of predominant inflammation. Among cells of the microenvironment, mesenchymal stem cells (MSCs) exhibiting ability to evolve into cancer associated fibroblasts (CAFs) have recently generated a major interest in the field. The physiological state of the tumor microenvironment is closely connected to discrete steps of tumorigenesis. The colon cancer cells elicit various factors with their direct interaction with MSCs or via paracrine fashion, which modulate these cells to promote cancer instead of performing their innate function of abating cancer progression. This review intends to highlight the necessity to exploit the cellular landscape of tumor microenvironment of colon cancer and a detailed understanding of the interactions between tumor epithelial cells and their stromal/inflammatory elements will aid in future perspectives for designing therapeutic regimens targeting tumor microenvironment to improve the clinical outcome of colon cancer.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Colon cancer; Cytokines; Mesenchymal stem cells; Metastasis; Targeted therapy; Tumor niche; microRNAs.

Added entries (persons, corporate bodies, meetings, titles ...)

Chabria, YashnaFaculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, India (author)
Kanna N. R., RajeshDepartment of Pathology, Faculty of Medicine, Chettinad Academy of Research & Education, Kelambakkam, Tamil Nadu, India (author)
Gopi, JananiFaculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, India (author)
Rowlo, PraveenFaculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, India (author)
Sun, Xiao-Feng,1959-Linköpings universitet,Institutionen för klinisk och experimentell medicin,Region Östergötland, Onkologiska kliniken US(Swepub:liu)xiasu45 (author)
Pathak, SurajitFaculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, India (author)
Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE) and Chettinad Hospital and Research Institute (CHRI), Kelambakkam, Tamil Nadu, IndiaDepartment of Pathology, Faculty of Medicine, Chettinad Academy of Research & Education, Kelambakkam, Tamil Nadu, India (creator_code:org_t)

Related titles

In:Cell Biology and Translational Medicine, Volume 13Cham : Springer, s. 177-19297830307905789783030790585

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https://libris.kb.se/bib/q481rbcsnpntj07kFind book at a swedish library/Hitta boken i ett svenskt bibliotek
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183838
https://doi.org/10.1007/5584_2019_355

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By the author/editor: Banerjee, Antara; Chabria, Yashna; Kanna N. R., Raj ...; Gopi, Janani; Rowlo, Praveen; Sun, Xiao-Feng, ...; show more...; Pathak, Surajit; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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