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CD4+CCR6+ T cells d...
CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature
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- Singhania, Akul (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Dubelko, Paige (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Kuan, Rebecca (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Chronister, William D. (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Muskat, Kaylin (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Das, Jyotirmoy (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Phillips, Elizabeth J. (författare)
- Murdoch Univ, Australia; Vanderbilt Univ, TN 37235 USA
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- Mallal, Simon A. (författare)
- Murdoch Univ, Australia; Vanderbilt Univ, TN 37235 USA
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- Seumois, Gregory (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Vijayanand, Pandurangan (författare)
- La Jolla Inst Immunol, CA 92037 USA
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- Sette, Alessandro (författare)
- La Jolla Inst Immunol, CA 92037 USA; Univ Calif San Diego, CA 92093 USA
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- Lerm, Maria (författare)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Peters, Bjoern (författare)
- La Jolla Inst Immunol, CA 92037 USA; Univ Calif San Diego, CA 92093 USA
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- Arlehamn, Cecilia Lindestam (författare)
- La Jolla Inst Immunol, CA 92037 USA
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 74
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://www.thelancet...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The century-old Mycobacterium bovis Bacillus Calmette-Guerin (BCG) remains the only licensed vaccine against tuberculosis (TB). Despite this, there is still a lot to learn about the immune response induced by BCG, both in terms of phenotype and specificity. Methods: We investigated immune responses in adult individuals pre and 8 months post BCG vaccination. We specifically determined changes in gene expression, cell subset composition, DNA methylome, and the TCR repertoire induced in PBMCs and CD4 memory T cells associated with antigen stimulation by either BCG or a Mycobacterium tuberculosis (Mtb)-derived peptide pool. Findings: Following BCG vaccination, we observed increased frequencies of CCR6+ CD4 T cells, which includes both Th1* (CXCR3+CCR6+) and Th17 subsets, and mucosal associated invariant T cells (MAITs). A large number of immune response genes and pathways were upregulated post BCG vaccination with similar patterns observed in both PBMCs and memory CD4 T cells, thus suggesting a substantial role for CD4 T cells in the cellular response to BCG. These upregulated genes and associated pathways were also reflected in the DNA methylome. We described both qualitative and quantitative changes in the BCG-specific TCR repertoire post vaccination, and importantly found evidence for similar TCR repertoires across different subjects. Interpretation: The immune signatures defined herein can be used to track and further characterize immune responses induced by BCG, and can serve as reference for benchmarking novel vaccination strategies. (C) 2021 The Author(s). Published by Elsevier B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- BCG; tuberculosis; T cell; Adaptive immunity; vaccine; transcriptomics; CCR6+ T cells
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Singhania, Akul
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Dubelko, Paige
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Kuan, Rebecca
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Chronister, Will ...
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Muskat, Kaylin
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Das, Jyotirmoy
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Phillips, Elizab ...
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Mallal, Simon A.
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Seumois, Gregory
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Vijayanand, Pand ...
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Sette, Alessandr ...
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Lerm, Maria
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Peters, Bjoern
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Arlehamn, Cecili ...
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