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Preterm birth and infant diurnal cortisol regulation

Stoye, David Q. (author)
Univ Edinburgh, Scotland
Boardman, James P. (author)
Univ Edinburgh, Scotland; Univ Edinburgh, Scotland
Osmond, Clive (author)
MRC Lifecourse Epidemiol Unit, England
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Sullivan, Gemma (author)
Univ Edinburgh, Scotland
Lamb, Gillian (author)
Univ Edinburgh, Scotland
Black, Gill S. (author)
Univ Edinburgh, Scotland
Homer, Natalie Z. M. (author)
Univ Edinburgh, Scotland
Nelson Follin, Nina (author)
Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Karolinska Inst, Sweden
Theodorsson, Elvar (author)
Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
Reynolds, Rebecca M. (author)
Univ Edinburgh, Scotland; Univ Edinburgh, Scotland
Morelius, Evalotte (author)
Edith Cowan Univ, Australia
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 (creator_code:org_t)
2022-03-14
2022
English.
In: Archives of Disease in Childhood. - : BMJ PUBLISHING GROUP. - 1359-2998 .- 1468-2052. ; 107:5, s. F565-F567
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. Methods A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linkoping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models. Results Compared with infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, 95% CI: -14.1 to 20.4), had a flattened diurnal slope across infancy. Conclusions Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

endocrinology; infant development

Publication and Content Type

ref (subject category)
art (subject category)

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