Endocrine and Mechanical Cardiacfunction Four Months after Radiofrequency Ablation of Atrialfibrillation.

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Charitakis, Emmanouil,1982-Linköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Kardiologiska kliniken US (author)

Endocrine and Mechanical Cardiacfunction Four Months after Radiofrequency Ablation of Atrialfibrillation.

Article/chapterEnglish2021

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2020-10-31
Overland Park, KS, United States :Cardiofront, Inc,2021
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LIBRIS-ID:oai:DiVA.org:liu-184177
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184177URI
https://doi.org/10.4022/jafib.20200454DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Funding: This study was supported by grants from the County Council of Östergötland, the Carldavid Jönsson Research Foundation, the Heart Foundation, Linköping University and by unrestricted grants from Biosense Webster, Johnson & Johnson.
Background: Radiofrequency ablation (RFA)is an important treatment option for patients with atrial fibrillation (AF). During RFA, a significant amount of energy is delivered into the left atrium (LA), resulting in considerable LA-injury. The impact of this damage on mechanical and endocrine LA-function, however, is often disregarded.We therefore aimed to evaluate the endocrine- and mechanical function of the heart 4-months after RFA of AF.Methods: In total 189 patients eligible for RFA of AF were studied. The levels of the N-terminal pro-B-natriuretic peptide (NT-proBNP) and the mid-regional fragment of the N-terminal pro-atrial natriuretic peptide (MR-proANP)were measured. The maximum LAvolume (LAVmax),the LAejection fraction (LAEF) and the LA peak longitudinal strain (PALS), were measured usingtransthoracic echocardiography. The measurements were performed before and 4-months after the intervention.Results: 87 patients had a recurrence during a mean follow-up of 143±36 days.NT-proBNPand MR-proANPdecreased significantly at follow-up. This reduction was greater in patients who did not suffer any recurrence after RFA.The LAVmax decreased significantly, whereasthe PALS only improved in patients who did not suffer from any recurrence. On the other hand, LAEF did not change significantly after RFA of AF.Conclusions: Despite extensiveablation during RFA of AF, the endocrine function of the heart improved 4-months after the index procedure. Patients with no arrhythmia recurrence showed a more pronounced improvement in their endocrinal function. Mechanically, the LAVmax was reduced, and the LA strain improved significantly.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Atrial fibrillation
Left Atrial Ejection Fraction
Left Atrial Strain
Natriuretic Peptides
Radiofrequency Ablation

Added entries (persons, corporate bodies, meetings, titles ...)

Karlsson, Lars O.Linköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)larka64 (author)
Carlhäll, Carl-Johan,1973-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)carca13 (author)
Liuba, Ioan,1969-Linköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)ioali65 (author)
Hassel Jönsson, AndersLinköpings universitet,Medicinska fakulteten,Avdelningen för diagnostik och specialistmedicin,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)n/a (author)
Walfridsson, Håkan,1949-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)hakwa83 (author)
Alehagen, Urban,1951-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten(Swepub:liu)urbal84 (author)
Linköpings universitetMedicinska fakulteten (creator_code:org_t)

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In:Journal of Atrial FibrillationOverland Park, KS, United States : Cardiofront, Inc14:11941-6911

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