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Long-term outcomes ...
Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia
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- Granholm, Anders (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Kjaer, Maj-Brit Norregaard (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Munch, Marie Warrer (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Myatra, Sheila Nainan (author)
- Tata Mem Hosp, India
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- Vijayaraghavan, Bharath Kumar Tirupakuzhi (author)
- Apollo Hosp, India; Chennai Crit Care Consultants, India; George Inst Global Hlth, India
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- Cronhjort, Maria (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Wahlin, Rebecka Rubenson (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Jakob, Stephan M. (author)
- Univ Bern, Switzerland
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- Cioccari, Luca (author)
- Univ Bern, Switzerland
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- Vesterlund, Gitte Kingo (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Meyhoff, Tine Sylvest (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Helleberg, Marie (author)
- Copenhagen Univ Hosp, Denmark
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- Moller, Morten Hylander (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark
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- Benfield, Thomas (author)
- Copenhagen Univ Hosp Amager & Hvidovre, Denmark
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- Venkatesh, Balasubramanian (author)
- Univ New South Wales, Australia
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- Hammond, Naomi E. (author)
- Univ New South Wales, Australia; Royal North Shore Hosp, Australia
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- Chew, Michelle S, 1969- (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Bassi, Abhinav (author)
- Chennai Crit Care Consultants, India
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- John, Oommen (author)
- Chennai Crit Care Consultants, India; Manipal Acad Higher Educ, India
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- Jha, Vivekanand (author)
- Chennai Crit Care Consultants, India; Manipal Acad Higher Educ, India; Imperial Coll London, England
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- Kristiansen, Klaus Tjelle (author)
- Univ Copenhagen, Denmark
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- Ulrik, Charlotte Suppli (author)
- Univ Copenhagen, Denmark
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- Jorgensen, Vibeke Lind (author)
- Copenhagen Univ Hosp, Denmark
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- Smitt, Margit (author)
- Copenhagen Univ Hosp, Denmark
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- Bestle, Morten H. (author)
- Copenhagen Univ Hosp North Zealand, Denmark; Univ Copenhagen, Denmark
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- Andreasen, Anne Sofie (author)
- Copenhagen Univ Hosp Herlev, Denmark
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- Poulsen, Lone Musaeus (author)
- Zealand Univ Hosp, Denmark
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- Rasmussen, Bodil Steen (author)
- Collaborat Res Intens Care CRIC, Denmark; Aalborg Univ Hosp, Denmark
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- Brochner, Anne Craveiro (author)
- Collaborat Res Intens Care CRIC, Denmark; Univ Hosp Southern Denmark, Denmark
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- Strom, Thomas (author)
- Odense Univ Hosp, Denmark; Univ Hosp Southern, Denmark
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- Moller, Anders (author)
- Naestved Slagelse Ringsted Hosp, Denmark
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- Khan, Mohd Saif (author)
- Rajendra Inst Med Sci, India
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- Padmanaban, Ajay (author)
- Apollo Hosp, India
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- Divatia, Jigeeshu Vasishtha (author)
- Tata Mem Hosp, India
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- Saseedharan, Sanjith (author)
- SL Raheja Hosp, India,Sir HN Reliance Fdn Hosp & Res Ctr, India,Herning Hosp, Denmark
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- Borawake, Kapil (author)
- Vishwaraj Hosp, India
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- Kapadia, Farhad (author)
- Hinduja Hosp, India
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- Dixit, Subhal (author)
- Sanjeevan Hosp, India
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- Chawla, Rajesh (author)
- Indraprastha Apollo Hosp, India
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- Shukla, Urvi (author)
- Symbiosis Univ Hosp & Res Ctr, India
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- Amin, Pravin (author)
- Bombay Hosp Inst Med Sci, India
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- Chew, Michelle S, 1969- (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Wamberg, Christian Aage (author)
- Bispebjerg Hosp, Denmark
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- Bose, Neeta (author)
- Gotri Gen Hosp, India
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- Shah, Mehul S. (author)
- Sir HN Reliance Fdn Hosp & Res Ctr, India
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- Darfelt, Iben S. (author)
- Herning Hosp, Denmark
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- Gluud, Christian (author)
- Copenhagen Univ Hosp, Denmark; Univ Southern Denmark, Denmark
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- Lange, Theis (author)
- Univ Copenhagen, Denmark
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- Perner, Anders (author)
- Rigshosp, Denmark; Collaborat Res Intens Care CRIC, Denmark; Univ New South Wales, Australia
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(creator_code:org_t)
- 2022-03-31
- 2022
- English.
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In: Intensive Care Medicine. - : SPRINGER. - 0342-4642 .- 1432-1238. ; 48, s. 580-589
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Purpose We assessed long-term outcomes of dexamethasone 12 mg versus 6 mg given daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia. Methods We assessed 180-day mortality and health-related quality of life (HRQoL) using EuroQoL (EQ)-5D-5L index values and EQ visual analogue scale (VAS) in the international, stratified, blinded COVID STEROID 2 trial, which randomised 1000 adults with confirmed COVID-19 receiving at least 10 L/min of oxygen or mechanical ventilation in 26 hospitals in Europe and India. In the HRQoL analyses, higher values indicated better outcomes, and deceased patients were given a score of zero. Results We obtained vital status at 180 days for 963 of 982 patients (98.1%) in the intention-to-treat population, EQ-5D-5L index value data for 922 (93.9%) and EQ VAS data for 924 (94.1%). At 180 days, 164 of 486 patients (33.7%) had died in the 12 mg group versus 184 of 477 (38.6%) in the 6 mg group [adjusted risk difference - 4.3%; 99% confidence interval (CI) - 11.7-3.0; relative risk 0.89; 0.72-1.09; P = 0.13]. The adjusted mean differences between the 12 mg and the 6 mg groups in EQ-5D-5L index values were 0.06 (99% CI - 0.01 to 0.12; P = 0.10) and in EQ VAS scores 4 (- 3 to 10; P = 0.22). Conclusion Among patients with COVID-19 and severe hypoxaemia, dexamethasone 12 mg compared with 6 mg did not result in statistically significant improvements in mortality or HRQoL at 180 days, but the results were most compatible with benefit from the higher dose.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- COVID-19; Hypoxaemia; Critical illness; Corticosteroids; Quality of life; Mortality
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Granholm, Anders
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Kjaer, Maj-Brit ...
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Munch, Marie War ...
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Myatra, Sheila N ...
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Vijayaraghavan, ...
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Cronhjort, Maria
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show more...
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Wahlin, Rebecka ...
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Jakob, Stephan M ...
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Cioccari, Luca
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Vesterlund, Gitt ...
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Meyhoff, Tine Sy ...
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Helleberg, Marie
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Moller, Morten H ...
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Benfield, Thomas
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Venkatesh, Balas ...
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Hammond, Naomi E ...
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Chew, Michelle S ...
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Bassi, Abhinav
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John, Oommen
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Jha, Vivekanand
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Kristiansen, Kla ...
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Ulrik, Charlotte ...
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Jorgensen, Vibek ...
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Smitt, Margit
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Bestle, Morten H ...
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Andreasen, Anne ...
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Poulsen, Lone Mu ...
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Rasmussen, Bodil ...
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Brochner, Anne C ...
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Strom, Thomas
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Moller, Anders
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Khan, Mohd Saif
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Padmanaban, Ajay
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Divatia, Jigeesh ...
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Saseedharan, San ...
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Borawake, Kapil
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Kapadia, Farhad
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Dixit, Subhal
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Chawla, Rajesh
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Shukla, Urvi
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Amin, Pravin
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Wamberg, Christi ...
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Bose, Neeta
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Shah, Mehul S.
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Darfelt, Iben S.
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Gluud, Christian
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Lange, Theis
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Perner, Anders
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Intensive Care M ...
- By the university
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Linköping University
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Karolinska Institutet