The effect of vascular endothelial growth factor-1 expression on survival of advanced colorectal cancer patients

• Colorectal cancer is third leading cause of cancer mortality. About 60% of patients hadalready developed metastasis at the time of diagnosis. Vascular endothelial growth factor(VEGF) is crucial for the development of neovascularization and hence metastasis. This studyaimed at investigating the relation between the expression of VEGF in biopsies from surgically dissected colon cancer and the survival of those patients. Biopsies were collected from86 patients with advanced colon cancer and sections were stained by immunohistochemistryfor VEGF. Patients received chemotherapy after the operation and were followed up fordisease progression and survival. The clinical data were statistically analyzed with respectto the immunohistochemistry results. The survival of the patients was significantly longer inthe patients for whom biopsies showed negative or weak expression of VEGF in comparisonto those with moderate to high expression (p-value = 0.04). The expression of VEGF was morefrequent in the patients who died as a consequence of the disease in comparison to the 10-year survivors. In conclusion, VEGF could be related to the survival of the patients withcolorectal carcinoma and should be considered as a predictor of the prognosis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Vascular endothelial growth factor; colorectal cancer; survival; oncology; angiogenesis; chemoresistance

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