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Evaluation of the r...
Evaluation of the robustness of cerebral oximetry to variations in skin pigmentation using a tissue-simulating phantom
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- Afshari, Ali (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Saager, Rolf B., 1974- (författare)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Burgos, David (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Vogt, William (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Wang, Jianting (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Mendoza, Gonzalo (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Weininger, Sandy (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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- Sung, Kung-Bin (författare)
- National Taiwan University, Graduate Institute of Biomedical Electronics and Bioinformatics, Taipei, Taiwan
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- Durkin, Anthony (författare)
- Department of Biomedical Engineering, University of California, Irvine, Natural Sciences II, Irvine, California, USA; Beckman Laser Institute & Medical Clinic, University of California, Irvine, East Irvine, California, USA
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- Pfefer, T. Joshua (författare)
- Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA
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(creator_code:org_t)
- 2022-04-21
- 2022
- Engelska.
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Ingår i: Biomedical Optics Express. - Washington, DC, United States : Optica Publishing Group. - 2156-7085. ; 13:5, s. 2909-2928
- Relaterad länk:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Clinical studies have demonstrated that epidermal pigmentation level can affect cerebral oximetry measurements. To evaluate the robustness of these devices, we have developed a phantom-based test method that includes an epidermis-simulating layer with several melanin concentrations and a 3D-printed cerebrovascular module. Measurements were performed with neonatal, pediatric and adult sensors from two commercial oximeters, where neonatal probes had shorter source-detector separation distances. Referenced blood oxygenation levels ranged from 30 to 90%. Cerebral oximeter outputs exhibited a consistent decrease in saturation level with simulated melanin content; this effect was greatest at low saturation levels, producing a change of up to 15%. Dependence on pigmentation was strongest in a neonatal sensor, possibly due to its high reflectivity. Overall, our findings indicate that a modular channel-array phantom approach can provide a practical tool for assessing the impact of skin pigmentation on cerebral oximeter performance and that modifications to algorithms and/or instrumentation may be needed to mitigate pigmentation bias.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
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Afshari, Ali
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Saager, Rolf B., ...
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Burgos, David
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Vogt, William
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Wang, Jianting
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Mendoza, Gonzalo
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visa fler...
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Weininger, Sandy
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Sung, Kung-Bin
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Durkin, Anthony
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Pfefer, T. Joshu ...
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Linköpings universitet