Pentraxin-3-a potential biomarker in ANCA-associated vasculitis

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Jonasdottir, A. D.Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)

Pentraxin-3-a potential biomarker in ANCA-associated vasculitis

Article/chapterEnglish2023

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2022-04-06
Taylor & Francis Ltd,2023
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LIBRIS-ID:oai:DiVA.org:liu-184536
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184536URI
https://doi.org/10.1080/03009742.2022.2045790DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:149249620URI

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Language:English
Summary in:English

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Funding Agencies|Swedish Kidney Foundation [F2019-0056, F2018-0045]; Swedish Renal Fund [2019]; Stockholm County CouncilStockholm County Council [SLL20180104, SLL20200277]
Objective The aim of this study was to investigate pentraxin-3 (PTX3) as a potential biomarker of inflammatory activity in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) at baseline and 6 month follow-up in a longitudinal cohort. Method Plasma PTX3 levels were measured in 79 newly diagnosed or relapsing AAV patients at baseline and 6 month follow-up, and in 23 healthy controls. Urinary PTX3 levels were measured in 34 of the patients. C-reactive protein (CRP), creatinine, and albuminuria were measured and the cumulative glucocorticoid dose at inclusion was calculated. The Birmingham Vasculitis Activity Score (BVAS) was assessed at baseline and follow-up. Results Plasma PTX3 levels were significantly higher at baseline than at 6 months (2.85 vs 1.23 ng/mL, p < 0.001). Plasma and urinary PTX3 levels correlated with BVAS at baseline (rho = 0.45, p < 0.001, and rho = 0.49, p = 0.008, respectively). A significant correlation between both plasma and urinary PTX3 levels and estimated glomerular filtration rate and albuminuria was found. However, there was no correlation between plasma and urinary PTX3 levels. At baseline, plasma and urinary PTX3 levels were significantly higher in patients with kidney involvement. PTX3 levels did not correlate with CRP, nor was there a correlation between CRP levels and BVAS at baseline. Conclusion Plasma and urinary PTX3 seem to reflect disease activity in AAV better than the commonly used CRP. PTX3 may have a potential role as a biomarker in monitoring disease activity in AAV patients, particularly in patients with kidney involvement.

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Antovic, A.Karolinska Institutet,Karolinska Inst, Sweden (author)
Qureshi, A. R.Karolinska Inst, Sweden (author)
Nordin, A.Karolinska Inst, Sweden (author)
Malmström, VKarolinska Institutet,Karolinska Inst, Sweden (author)
Gunnarsson, IKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (author)
Bruchfeld, AnnetteLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden(Swepub:liu)anbru14 (author)
Karolinska InstitutetKarolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (creator_code:org_t)

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In:Scandinavian Journal of Rheumatology: Taylor & Francis Ltd52:3, s. 293-3010300-97421502-7732

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