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Impact of Interleuk...
Impact of Interleukin-28B gene polymorphism [rs12979860] on Egyptian patients infected with hepatitis C virus genotype-4
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- Ibrahim, G.H. (author)
- Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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- Khalil, F.A. (author)
- Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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- El Abaseri, T.B. (author)
- Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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- Attia, F.M. (author)
- Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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- El-Serafi, Ahmed Taher, 1977- (author)
- Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
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(creator_code:org_t)
- 2013-12-01
- 2013
- English.
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In: Eastern Mediterranean Health Journal. - Alexandria, Egypt : World Health Organization Regional Office for the Eastern Mediterranean (WHO/EMRO). - 1020-3397 .- 1687-1634. ; 19:Supp. 3, s. 98-104
- Related links:
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https://doi.org/10.2...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon-α-ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. A similar role was investigated in a case-control study conducted on 93 Egyptian patients chronically infected with HCV-4 in comparison to 22 individuals with spontaneous HCV clearance and 70 healthy volunteers. The homozygous C allele genotype (CC) was associated with sustained viral response (SVR) to therapy compared with the homozygous T allele genotype (TT) and the heterozygous genotype (CT). In the SVR group, the response rate was statistically significantly higher in CC genotypes (58.6%) compared with CT/TT (20.3%). There was no correlation between SVR patients' genotypes and early response to therapy or HCV baseline viral load. Our findings describe how IL-28B SNP genotyping may guide appropriate selection of HCV-4-infected patients for PR therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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