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AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi)
 

Search: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi) > (2010-2014) > Identification of a...

  • Franck, NiclasLinköpings universitet,Internmedicin,Hälsouniversitetet,Linköping University (author)

Identification of adipocyte genes regulated by caloric intake

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Endocrine society,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-18464
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18464URI
  • https://doi.org/10.1210/jc.2009-2534DOI
  • https://research.chalmers.se/publication/130448URI
  • https://gup.ub.gu.se/publication/130448URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • CONTEXT: Changes in energy intake have marked and rapid effects on metabolic functions and some of the effects may be due to changes in adipose tissue gene expression that precede alterations in body weight. OBJECTIVE: To identify genes in adipose tissue regulated by changes in caloric intake independent of changes in body weight. RESEARCH DESIGN AND METHODS: Obese subjects were given a very-low calorie diet (VLCD; 450 kcal/day) for 16 weeks. After the diet, ordinary food was gradually reintroduced during 2 weeks while there were minimal changes in body weight. Adipose tissue gene expression was measured by microarray analysis. First, genes regulated during caloric restriction and in the opposite direction during the weight stable re-feeding phase were identified. To verify opposite regulation to that observed during caloric restriction, identified genes were further analyzed using adipocyte expression profiles from healthy subjects before and after overfeeding. Results were confirmed using real time PCR or immunoassay. RESULTS: Using a significance level of p<0.05 for all comparisons, 52 genes were downregulated and 50 were up-regulated by caloric restriction and regulated in the opposite direction by re-feeding and overfeeding. Among these were genes that affect lipogenesis (ACLY, ACACA, FASN, SCD), protein synthesis (4EBP1, 4EBP2), beta-oxidation (CPT1B), liberation of fatty acids (CIDEA) and glyceroneogenesis (PCK2). Interestingly, several of these are under control of the master regulator mTOR. CONCLUSIONS: The observed transcriptional changes indicate that mTOR plays a central role in the control of diet-regulated adipocyte genes involved in lipogenesis and protein synthesis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Gummesson, Anders,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xguman (author)
  • Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xjernm (author)
  • Guillot, GillesDepartment of Mathematical Statistics, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden; Applied Mathematics and Computer Sciences Department,National Research Institute for Agronomy, Paris, France; Centre for Ecology and Evolutionary Synthesis, Department of Biology, University of Oslo, Oslo, Norway,Danmarks Tekniske Universitet,Technical University of Denmark (author)
  • Glad, Camilla A M,1981Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xglaca (author)
  • Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden;(Swepub:gu)xsvper (author)
  • Rudemo, Mats,1937Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Department of Mathematical Statistics, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden(Swepub:cth)rudemo (author)
  • Nyström, Fredrik H.Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US,Linköping University(Swepub:liu)freny92 (author)
  • Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xcarle (author)
  • Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xolsbo (author)
  • Linköpings universitetInternmedicin (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: Endocrine society96:2, s. E413-E4180021-972X1945-7197

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