Hepatocyte growth factor, colony-stimulating factor 1, CD40, and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:liu-184709" > Hepatocyte growth f...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Bäckryd, EmmanuelLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Pain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden (author)

Hepatocyte growth factor, colony-stimulating factor 1, CD40, and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study

Article/chapterEnglish2022

Publisher, publication year, extent ...

2021-08-24
LIPPINCOTT WILLIAMS & WILKINS,2022
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:liu-184709
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-184709URI
https://doi.org/10.1097/j.pain.0000000000002451DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-451521URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|NEURO Sweden; ALF Research Grants, Region Ostergotland; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02470]; European CommissionEuropean CommissionEuropean Commission Joint Research Centre [ID633491]; International Diabetic Neuropathy Consortium - Novo Nordisk Foundation [NNF14SA0006]; Academy of Medical Sciences Starter Grant [SGL022\1086]
One in 5 patients with diabetes suffers from chronic pain with neuropathic characteristics, but the pathophysiological mechanisms underlying the development of neuropathic pain in patients with diabetic distal symmetrical polyneuropathy (DSP) are poorly understood. Systemic low-grade inflammation has been implicated, but there is still a considerable knowledge gap concerning its scope and meaning in this context. The aim of the study was to establish the broad inflammatory signature of painful diabetic DSP in serum samples from the Pain in Neuropathy Study, an observational cross-sectional multicentre study in which participants underwent deep phenotyping. In the present two cohorts exploration-replication study (180 participants in each cohort), serum samples from Pain in Neuropathy Study participants were analyzed with the Olink INFLAMMATION panel (Olink Bioscience, Uppsala, Sweden) that enables the simultaneous measurement of 92 inflammation-related proteins (mainly cytokines, chemokines, and growth factors). In both the exploration and the replication cohort, we identified a high-inflammation subgroup where 14 inflammation-related proteins in particular were associated with more neuropathy and higher pain intensity. The top 3 proteins were hepatocyte growth factor, colony-stimulating factor 1, and CD40 in both cohorts. In the exploratory cohort, additional clinical data were available, showing an association of inflammation with insomnia and self-reported psychological distress. Hence, this cross-sectional exploration-replication study seems to confirm that low-grade systemic inflammation is related to the severity of neuropathy and neuropathic pain in a subgroup of patients with diabetic DSP. The pathophysiological relevance of these proteins for the development of neuropathic pain in patients with diabetic DSP must be explored in more depth in future studies.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Biomarker; Chronic pain; Diabetes; Inflammation; Neuropathic; Neuropathy; Pain; Polyneuropathy

Added entries (persons, corporate bodies, meetings, titles ...)

Themistocleous, AndreasUniv Oxford, England,Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK (author)
Larsson, AndersUppsala universitet,Klinisk kemi,Uppsala Univ, Sweden(Swepub:uu)andlarss (author)
Gordh, TorstenUppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden(Swepub:uu)torsgord (author)
Rice, Andrew S. C.Imperial Coll London, England,Pain Research, Dept Surgery and Cancer, Faculty of Medicine, Imperial College London, United Kingdom (author)
Tesfaye, SolomonSheffield Teaching Hosp NHS Fdn Trust, England,Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK (author)
Bennett, David L.Univ Oxford, England,Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK (author)
Gerdle, BjörnLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,Pain and Rehabilitation Center, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:liu)bjoge88 (author)
Linköpings universitetAvdelningen för prevention, rehabilitering och nära vård (creator_code:org_t)

Related titles

In:Pain: LIPPINCOTT WILLIAMS & WILKINS163:5, s. 897-9090304-39591872-6623

Internet link

Find in a library

Pain (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Bäckryd, Emmanue ...; Themistocleous, ...; Larsson, Anders; Gordh, Torsten; Rice, Andrew S. ...; Tesfaye, Solomon; show more...; Bennett, David L ...; Gerdle, Björn; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Rheumatology and ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Anesthesiology a ...

Articles in the publication: Pain

By the university: Linköping University; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se