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Cardiac remodelling...
Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
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- Gonzalez, Arantxa (author)
- Univ Navarra, Spain; Navarra Inst Hlth Res, Spain; Carlos III Inst Hlth, Spain
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- Richards, A. Mark (author)
- Natl Univ Singapore, Singapore; Univ Otago, New Zealand
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- de Boer, Rudolf A. (author)
- Univ Groningen, Netherlands
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- Thum, Thomas (author)
- Hannover Med Sch, Germany; Hannover Med Sch, Germany; Fraunhofer Inst Toxicol & Expt Med, Germany
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- Arfsten, Henrike (author)
- Med Univ Vienna, Austria; German Ctr Cardiovasc Res DZHK, Germany
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- Hulsmann, Martin (author)
- Med Univ Vienna, Austria
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- Falcao-Pires, Ines (author)
- Univ Porto, Portugal
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- Diez, Javier (author)
- Univ Navarra, Spain; Navarra Inst Hlth Res, Spain; Carlos III Inst Hlth, Spain; Clin Univ Navarra, Spain; Clin Univ Navarra, Spain
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- Foo, Roger S. Y. (author)
- Natl Univ Singapore, Singapore
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- Chan, Mark Y. (author)
- Natl Univ Singapore, Singapore
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- Aimo, Alberto (author)
- Scuola Super Sant Anna, Italy; Fdn Toscana Gabriele Monasterio, Italy
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- Anene-Nzelu, Chukwuemeka G. (author)
- Natl Univ Singapore, Singapore; Montreal Heart Inst, Canada
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- Abdelhamid, Magdy (author)
- Cairo Univ, Egypt
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- Adamopoulos, Stamatis (author)
- Onassis Cardiac Surg Ctr, Greece
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- Anker, Stefan D. (author)
- Charite, Germany; Charite Univ Med Berlin, Germany; Charite Univ Med Berlin, Germany; Wroclaw Med Univ, Poland
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- Belenkov, Yuri (author)
- Lomonosv Moscow State Univ, Russia
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- Gal, Tuvia B. (author)
- Rabin Med Ctr, Israel
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- Cohen-Solal, Alain (author)
- Hosp Lariboisiere, France
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- Boehm, Michael (author)
- Saarland Univ, Germany
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- Chioncel, Ovidiu (author)
- Univ Med & Pharm Carol Davila, Romania
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- Delgado, Victoria (author)
- Hosp Badalona Germans Trias & Pujol, Spain
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- Emdin, Michele (author)
- Scuola Super Sant Anna, Italy; Fdn Toscana Gabriele Monasterio, Italy
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- Jankowska, Ewa A. (author)
- Wroclaw Med Univ, Poland
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- Gustafsson, Finn (author)
- Copenhagen Univ Hosp, Denmark
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- Hill, Loreena (author)
- Karolinska Institutet
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- Jaarsma, Tiny (author)
- Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten
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- Januzzi, James L. (author)
- Massachusetts Gen Hosp, MA 02114 USA; Baim Inst Clin Res, MA USA
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- Jhund, Pardeep S. (author)
- Univ Glasgow, Scotland
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- Lopatin, Yuri (author)
- Volgograd State Med Univ, Russia
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- Lund, Lars H. (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Metra, Marco (author)
- Univ Brescia, Italy; Univ Brescia, Italy
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- Milicic, Davor (author)
- Univ Zagreb, Croatia
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- Moura, Brenda (author)
- Univ Porto, Portugal; Porto Armed Forces Hosp, Portugal
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- Mueller, Christian (author)
- Univ Hosp, Switzerland
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- Mullens, Wilfried (author)
- Hosp Oost Limburg, Belgium
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- Nunez, Julio (author)
- Carlos III Inst Hlth, Spain; Univ Valencia, Spain
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- Piepoli, Massimo F. (author)
- Castelsangiovanni Hosp, Italy
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- Rakisheva, Amina (author)
- Sci Res Inst Cardiol & Internal Med, Kazakhstan
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- Ristic, Arsen D. (author)
- Univ Clin Ctr Serbia, Serbia; Univ Belgrade, Serbia
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- Rossignol, Patrick (author)
- Univ Lorraine, France; CHRU Nancy, France
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- Savarese, Gianluigi (author)
- Karolinska Institutet
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- Tocchetti, Carlo G. (author)
- Univ Naples Federico II, Italy
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- Van Linthout, Sophie (author)
- German Ctr Cardiovasc Res DZHK, Germany; Charite Univ Med Berlin, Germany
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- Volterrani, Maurizio (author)
- IRCCS San Raffaele, Italy
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- Seferovic, Petar (author)
- Univ Belgrade, Serbia; Serbian Acad Arts & Sci, Serbia
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- Rosano, Giuseppe (author)
- Univ London, England
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- Coats, Andrew J. S. (author)
- Univ Warwick, England
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- Bayes-Genis, Antoni (author)
- Carlos III Inst Hlth, Spain; Hosp Badalona Germans Trias & Pujol, Spain; Univ Autonoma Barcelona, Spain
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(creator_code:org_t)
- 2022-04-21
- 2022
- English.
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In: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 24:6, s. 927-943
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Cardiac remodelling refers to changes in left ventricular structure and function over time, with a progressive deterioration that may lead to heart failure (HF) development (adverse remodelling) or vice versa a recovery (reverse remodelling) in response to HF treatment. Adverse remodelling predicts a worse outcome, whilst reverse remodelling predicts a better prognosis. The geometry, systolic and diastolic function and electric activity of the left ventricle are affected, as well as the left atrium and on the long term even right heart chambers. At a cellular and molecular level, remodelling involves all components of cardiac tissue: cardiomyocytes, fibroblasts, endothelial cells and leucocytes. The molecular, cellular and histological signatures of remodelling may differ according to the cause and severity of cardiac damage, and clearly to the global trend toward worsening or recovery. These processes cannot be routinely evaluated through endomyocardial biopsies, but may be reflected by circulating levels of several biomarkers. Different classes of biomarkers (e.g. proteins, non-coding RNAs, metabolites and/or epigenetic modifications) and several biomarkers of each class might inform on some aspects on HF development, progression and long-term outcomes, but most have failed to enter clinical practice. This may be due to the biological complexity of remodelling, so that no single biomarker could provide great insight on remodelling when assessed alone. Another possible reason is a still incomplete understanding of the role of biomarkers in the pathophysiology of cardiac remodelling. Such role will be investigated in the first part of this review paper on biomarkers of cardiac remodelling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Biomarkers; Remodeling; Cells; Tissue
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Gonzalez, Arantx ...
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Richards, A. Mar ...
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de Boer, Rudolf ...
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Thum, Thomas
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Arfsten, Henrike
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Hulsmann, Martin
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show more...
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Falcao-Pires, In ...
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Diez, Javier
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Foo, Roger S. Y.
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Chan, Mark Y.
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Aimo, Alberto
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Anene-Nzelu, Chu ...
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Abdelhamid, Magd ...
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Adamopoulos, Sta ...
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Anker, Stefan D.
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Belenkov, Yuri
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Gal, Tuvia B.
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Cohen-Solal, Ala ...
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Boehm, Michael
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Chioncel, Ovidiu
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Delgado, Victori ...
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Emdin, Michele
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Jankowska, Ewa A ...
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Gustafsson, Finn
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Hill, Loreena
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Jaarsma, Tiny
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Januzzi, James L ...
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Jhund, Pardeep S ...
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Lopatin, Yuri
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Lund, Lars H.
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Metra, Marco
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Milicic, Davor
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Moura, Brenda
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Mueller, Christi ...
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Mullens, Wilfrie ...
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Nunez, Julio
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Piepoli, Massimo ...
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Rakisheva, Amina
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Ristic, Arsen D.
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Rossignol, Patri ...
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Savarese, Gianlu ...
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Tocchetti, Carlo ...
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Van Linthout, So ...
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Volterrani, Maur ...
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Seferovic, Petar
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Rosano, Giuseppe
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Coats, Andrew J. ...
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Bayes-Genis, Ant ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Journal ...
- By the university
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Linköping University
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Karolinska Institutet