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Histological diseas...
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Olsen, Laerke MüllerRoskilde, Denmark
(författare)
Histological disease activity in patients with microscopic colitis is not related to clinical disease activity or long-term prognosis
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-05-21
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Chichester, United Kingdom :Wiley-Blackwell,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-185088
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185088URI
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https://doi.org/10.1111/apt.16381DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding: The study was funded by Dr Johan Bohr, Örebro Universitets Hospital, Medicin Kliniken, Örebro and by Dr Falk Pharma GMBH, Leinenweberstrasse 5, 79108 Freiburg, Germany.
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Background Microscopic colitis (MC) is a common cause of chronic watery diarrhea. Biopsies with characteristic histological features are crucial for establishing the diagnosis. The two main subtypes are collagenous colitis (CC) and lymphocytic colitis (LC) but incomplete forms exist. The disease course remains unpredictable varying from spontaneous remission to a relapsing course.Aim To identify possible histological predictors of course of disease.Methods Sixty patients from the European prospective MC registry (PRO-MC Collaboration) were included. Digitised histological slides stained with CD3 and Van Gieson were available for all patients. Total cell density and proportion of CD3 positive lymphocytes in lamina propria and surface epithelium were estimated by automated image analysis, and measurement of the subepithelial collagenous band was performed. Histopathological features were correlated to the number of daily stools and daily watery stools at time of endoscopy and at baseline as well as the clinical disease course (quiescent, achieved remission after treatment, relapsing or chronic active) at 1-year follow-up.Results Neither total cell density in lamina propria, proportion of CD3 positive lymphocytes in lamina propria or surface epithelium, or thickness of collagenous band showed significant correlation to the number of daily stools or daily watery stools at any point of time. None of the assessed histological parameters at initial diagnosis were able to predict clinical disease course at 1-year follow-up.Conclusions Our data indicate that the evaluated histological parameters were neither markers of disease activity at the time of diagnosis nor predictors of disease course.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Engel, Peter Johan HeibergRoskilde, Denmark
(författare)
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Goudkade, DannyGeleen, The Netherlands
(författare)
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Villanacci, VincenzoBrescia, Italy
(författare)
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Thagaard, JeppeHoersholm, Denmark; Lyngby, Denmark
(författare)
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Walbech, Julie SparholtKøge, Denmark
(författare)
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Bohr, JohanÖrebro, Sweden
(författare)
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Kupcinskas, JuozasKaunas, Lithuania
(författare)
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Verhaegh, BasMaastricht, The Netherlands
(författare)
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Münch, Andreas,1970-Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken(Swepub:liu)andsa76
(författare)
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Guagnozzi, DanilaBarcelona, Spain
(författare)
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Fernández-Bañares, FernandoBarcelona, Spain
(författare)
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Munck, Lars KristianKøge, Denmark; Copenhagen, Denmark
(författare)
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Fiehn, Anne-Marie KanstrupRoskilde, Denmark; Køge, Denmark; Copenhagen, Denmark
(författare)
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Roskilde, DenmarkGeleen, The Netherlands
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Alimentary Pharmacology and TherapeuticsChichester, United Kingdom : Wiley-Blackwell54:1, s. 43-520269-28131365-2036
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Olsen, Laerke Mü ...
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Engel, Peter Joh ...
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Goudkade, Danny
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Thagaard, Jeppe
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Walbech, Julie S ...
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Bohr, Johan
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