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Clinical manifestat...
Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysis
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- Lee, Christine J. (författare)
- New York Inst Technol, NY 11568 USA
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- Woo, Wongi (författare)
- Yonsei Univ, South Korea
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- Kim, Ah Young (författare)
- Kyung Hee Univ, South Korea; Yonsei Univ, South Korea
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- Yon, Dong Keon (författare)
- Yonsei Univ, South Korea; Kyung Hee Univ, South Korea
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- Lee, Seung Won (författare)
- Sejong Univ, South Korea; Sungkyunkwan Univ, South Korea
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- Koyanagi, Ai (författare)
- Univ Barcelona, Spain; Pg Lluis Co 23, Spain
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- Kim, Min Seo (författare)
- Sungkyunkwan Univ, South Korea
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- Tizaoui, Kalthoum (författare)
- Tunis El Manar Univ, Tunisia
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- Dragioti, Elena, Ph.D. (författare)
- Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Radua, Joaquim (författare)
- CIBERSAM, Spain; Karolinska Inst, Sweden; Kings Coll London, England
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- Lee, Sungsoo (författare)
- Yonsei Univ, South Korea
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- Smith, Lee (författare)
- Anglia Ruskin Univ, England
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- Il Shin, Jae (författare)
- Kyung Hee Univ, South Korea
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(creator_code:org_t)
- 2022-06
- 2022
- Engelska.
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Ingår i: Journal of Medical Virology. - : WILEY. - 0146-6615 .- 1096-9071. ; 94:9, s. 4234-4245
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- To provide a comparative meta-analysis and systematic review of the risk and clinical outcomes of coronavirus 2019 (COVID-19) infection between fully vaccinated and unvaccinated groups. Eighteen studies of COVID-19 infections in fully vaccinated ("breakthrough infections") and unvaccinated individuals were reviewed from Medline/PubMed, Scopus, Embase, and Web of Science databases. The meta-analysis examined the summary effects and between-study heterogeneity regarding differences in the risk of infection, hospitalization, treatments, and mortality between vaccinated and unvaccinated individuals. he overall risk of infection was lower for the fully vaccinated compared to that of the unvaccinated (relative risk [RR] 0.20, 95% confidence interval [CI]: 0.19-0.21), especially for variants other than Delta (Delta: RR 0.29, 95% CI: 0.13-0.65; other variants: RR 0.06, 95% CI: 0.04-0.08). The risk of asymptomatic infection was not statistically significantly different between fully vaccinated and unvaccinated (RR 0.56, 95% CI: 0.27-1.19). There were neither statistically significant differences in risk of hospitalization (RR 1.06, 95% CI: 0.38-2.93), invasive mechanical ventilation (RR 1.65, 95% CI: 0.90-3.06), or mortality (RR 1.19, 95% CI: 0.79-1.78). Conversely, the risk of supplemental oxygen during hospitalization was significantly higher for the unvaccinated (RR 1.40, 95% CI: 1.08-1.82). Unvaccinated people were more vulnerable to COVID-19 infection than fully vaccinated for all variants. Once infected, there were no statistically significant differences in the risk of hospitalization, invasive mechanical ventilation, or mortality. Still, unvaccinated showed an increased need for oxygen supplementation. Further prospective analysis, including patients risk factors, COVID-19 variants, and the utilized treatment strategies, would be warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- breakthrough infection; clinical manifestations; COVID-19; Delta variant; vaccine effectiveness
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Lee, Christine J ...
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Woo, Wongi
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Kim, Ah Young
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Yon, Dong Keon
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Lee, Seung Won
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Koyanagi, Ai
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Kim, Min Seo
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Tizaoui, Kalthou ...
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Dragioti, Elena, ...
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Radua, Joaquim
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Lee, Sungsoo
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Smith, Lee
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Il Shin, Jae
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Journal of Medic ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet