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Clinical manifestat...
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Lee, Christine J.New York Inst Technol, NY 11568 USA
(författare)
Clinical manifestations of COVID-19 breakthrough infections: A systematic review and meta-analysis
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-06
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WILEY,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-185820
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185820URI
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https://doi.org/10.1002/jmv.27871DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149686090URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:for swepub-publicationtype
Anmärkningar
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To provide a comparative meta-analysis and systematic review of the risk and clinical outcomes of coronavirus 2019 (COVID-19) infection between fully vaccinated and unvaccinated groups. Eighteen studies of COVID-19 infections in fully vaccinated ("breakthrough infections") and unvaccinated individuals were reviewed from Medline/PubMed, Scopus, Embase, and Web of Science databases. The meta-analysis examined the summary effects and between-study heterogeneity regarding differences in the risk of infection, hospitalization, treatments, and mortality between vaccinated and unvaccinated individuals. he overall risk of infection was lower for the fully vaccinated compared to that of the unvaccinated (relative risk [RR] 0.20, 95% confidence interval [CI]: 0.19-0.21), especially for variants other than Delta (Delta: RR 0.29, 95% CI: 0.13-0.65; other variants: RR 0.06, 95% CI: 0.04-0.08). The risk of asymptomatic infection was not statistically significantly different between fully vaccinated and unvaccinated (RR 0.56, 95% CI: 0.27-1.19). There were neither statistically significant differences in risk of hospitalization (RR 1.06, 95% CI: 0.38-2.93), invasive mechanical ventilation (RR 1.65, 95% CI: 0.90-3.06), or mortality (RR 1.19, 95% CI: 0.79-1.78). Conversely, the risk of supplemental oxygen during hospitalization was significantly higher for the unvaccinated (RR 1.40, 95% CI: 1.08-1.82). Unvaccinated people were more vulnerable to COVID-19 infection than fully vaccinated for all variants. Once infected, there were no statistically significant differences in the risk of hospitalization, invasive mechanical ventilation, or mortality. Still, unvaccinated showed an increased need for oxygen supplementation. Further prospective analysis, including patients risk factors, COVID-19 variants, and the utilized treatment strategies, would be warranted.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Woo, WongiYonsei Univ, South Korea
(författare)
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Kim, Ah YoungKyung Hee Univ, South Korea; Yonsei Univ, South Korea
(författare)
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Yon, Dong KeonYonsei Univ, South Korea; Kyung Hee Univ, South Korea
(författare)
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Lee, Seung WonSejong Univ, South Korea; Sungkyunkwan Univ, South Korea
(författare)
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Koyanagi, AiUniv Barcelona, Spain; Pg Lluis Co 23, Spain
(författare)
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Kim, Min SeoSungkyunkwan Univ, South Korea
(författare)
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Tizaoui, KalthoumTunis El Manar Univ, Tunisia
(författare)
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Dragioti, Elena,Ph.D.Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum(Swepub:liu)eledr71
(författare)
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Radua, JoaquimCIBERSAM, Spain; Karolinska Inst, Sweden; Kings Coll London, England
(författare)
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Lee, SungsooYonsei Univ, South Korea
(författare)
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Smith, LeeAnglia Ruskin Univ, England
(författare)
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Il Shin, JaeKyung Hee Univ, South Korea
(författare)
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New York Inst Technol, NY 11568 USAYonsei Univ, South Korea
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Medical Virology: WILEY94:9, s. 4234-42450146-66151096-9071
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Till lärosätets databas
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Lee, Christine J ...
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Woo, Wongi
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Kim, Ah Young
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Yon, Dong Keon
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Lee, Seung Won
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Koyanagi, Ai
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visa fler...
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Kim, Min Seo
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Tizaoui, Kalthou ...
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Dragioti, Elena, ...
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Radua, Joaquim
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Lee, Sungsoo
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Smith, Lee
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Il Shin, Jae
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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Journal of Medic ...
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Linköpings universitet
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Karolinska Institutet