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Placental Tissue De...
Placental Tissue Destruction and Insufficiency From COVID-19 Causes Stillbirth and Neonatal Death From Hypoxic-Ischemic Injury
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- Schwartz, David A. (author)
- Perinatal Pathol, GA 30322 USA
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- Avvad-Portari, Elyzabeth (author)
- Fiocruz MS, Brazil
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- Babal, Pavel (author)
- Comenius Univ, Slovakia
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- Baldewijns, Marcella (author)
- Univ Hosp Leuven, Belgium
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- Blomberg, Marie (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US
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- Bouachba, Amine (author)
- Hosp Civils Lyon, France; SOFFOET Soc Francaise Fooetopathol, France
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- Camacho, Jessica (author)
- Hosp Univ Vall dHebron, Spain
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- Collardeau-Frachon, Sophie (author)
- SOFFOET Soc Francaise Fooetopathol, France; Univ Claude Bernard Lyon 1, France
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- Colson, Arthur (author)
- Catholic Univ Louvain, Belgium
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- Dehaene, Isabelle (author)
- Ghent Univ Hosp, Belgium
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- Carles Ferreres, Joan (author)
- Parc Tauli Hosp Univ, Spain; Univ Autonoma Barcelona, Spain
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- Fitzgerald, Brendan (author)
- Cork Univ Hosp, Ireland
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- Garrido-Pontnou, Marta (author)
- Hosp Univ Vall dHebron, Spain; Univ Autonoma Barcelona, Spain
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- Gergis, Hazem (author)
- Doncaster & Bassetlaw NHS Teaching Hosp, England
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- Hargitai, Beata (author)
- NHS Fdn Trust, England
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- Cecilia Helguera-Repetto, A. (author)
- Natl Inst Perinatol, Mexico
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- Holmstrom, Sandra (author)
- Halland Hosp, Sweden
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- Liliane Irles, Claudine (author)
- Natl Inst Perinatol Isidro Espinosa de los Reyes, Mexico
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- Leijonhfvud, Asa (author)
- Lund Univ, Sweden
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- Libbrecht, Sasha (author)
- Antwerp Univ Hosp, Belgium
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- Marton, Tamas (author)
- Birmingham Womens Hosp, England
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- McEntagart, Noel (author)
- Rotunda Hosp, Ireland
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- Molina, James T. (author)
- CHRISTUS Hosp St Elizabeth, TX USA
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- Morotti, Raffaella (author)
- Yale Univ, CT USA
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- Nadal, Alfons (author)
- Hosp Clin Barcelona, Spain; Univ Barcelona, Spain; August Pi & Sunyer Biomed Res Inst IDIBAPS, Spain
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- Navarro, Alexandra (author)
- Hosp Univ Vall dHebron, Spain
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- Nelander, Maria (author)
- Uppsala Univ, Sweden
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- Oviedo, Angelica (author)
- Burrell Coll Osteopath Med, NM USA
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- Oyamada Otani, Andre Ricardo (author)
- Lab Ferdinando Costa, Brazil
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- Papadogiannakis, Nikos (author)
- Karolinska Institutet
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- Petersen, Astrid C. (author)
- Aalborg Univ Hosp, Denmark
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- Roberts, Drucilla J. (author)
- Harvard Med Sch, MA 02115 USA
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- Saad, Ali G. (author)
- Karolinska Institutet
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- Sand, Anna (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Schoenmakers, Sam (author)
- Erasmus MC Univ Med Ctr Rotterdam, Netherlands
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- Sehn, Jennifer K. (author)
- St Louis Univ, MO 63104 USA
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- Simpson, Preston R. (author)
- CHRISTUS Hosp St Elizabeth, TX USA
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- Thomas, Kristen (author)
- NYU, NY USA; NYU, NY USA
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- Yolotzin Valdespino-Vazquez, M. (author)
- Univ Hosp Leuven, Belgium; Natl Inst Perinatol, Mexico
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- van der Meeren, Lotte E. (author)
- Leiden Univ Med Ctr, Netherlands; Univ Med Ctr Utrecht, Netherlands
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- Van Dorpe, Jo (author)
- Ghent Univ Hosp, Belgium
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- Verdijk, Robert M. (author)
- Erasmus MC Univ Med Ctr Rotterdam, Netherlands
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- Watkins, Jaclyn C. (author)
- Harvard Med Sch, MA 02115 USA
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- Zaigham, Mehreen (author)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden; Skane Univ Hosp, Sweden
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(creator_code:org_t)
- COLL AMER PATHOLOGISTS, 2022
- 2022
- English.
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In: Archives of Pathology & Laboratory Medicine. - : COLL AMER PATHOLOGISTS. - 0003-9985 .- 1543-2165. ; 146:6, s. 660-676
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.5...
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http://kipublication...
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Abstract
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- Context.-Perinatal death is an increasingly important problem as the coronavirus disease 2019 (COVID-19) pandemic continues, but the mechanism of death has been unclear. Objective.-To evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Design.-Case-based retrospective clinicopathologic analysis by a multinational group of 44 perinatal specialists from 12 countries of placental and autopsy pathology findings from 64 stillborns and 4 neonatal deaths having placentas testing positive for SARS-CoV-2 following delivery to mothers with COVID-19. Results.-Of the 3 findings constituting SARS-CoV-2 placentitis, all 68 placentas had increased fibrin deposition and villous trophoblast necrosis and 66 had chronic histiocytic intervillositis. Sixty-three placentas had massive perivillous fibrin deposition. Severe destructive placental disease from SARS-CoV-2 placentitis averaged 77.7% tissue involvement. Other findings included multiple intervillous thrombi (37%; 25 of 68) and chronic villitis (32%; 22 of 68). The majority (19; 63%) of the 30 autopsies revealed no significant fetal abnormalities except for intrauterine hypoxia and asphyxia. Among all 68 cases, SARS-CoV-2 was detected from a body specimen in 16 of 28 cases tested, most frequently from nasopharyngeal swabs. Four autopsied stillborns had SARS-CoV-2 identified in internal organs. Conclusions.-The pathology abnormalities composing SARS-CoV-2 placentitis cause widespread and severe placental destruction resulting in placental malperfusion and insufficiency. In these cases, intrauterine and perinatal death likely results directly from placental insufficiency and fetal hypoxic-ischemic injury. There was no evidence that SARS-CoV-2 involvement of the fetus had a role in causing these deaths.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Schwartz, David ...
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Avvad-Portari, E ...
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Babal, Pavel
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Baldewijns, Marc ...
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Blomberg, Marie
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Bouachba, Amine
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Camacho, Jessica
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Collardeau-Frach ...
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Colson, Arthur
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Dehaene, Isabell ...
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Carles Ferreres, ...
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Fitzgerald, Bren ...
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Garrido-Pontnou, ...
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Gergis, Hazem
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Hargitai, Beata
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Cecilia Helguera ...
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Holmstrom, Sandr ...
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Liliane Irles, C ...
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Leijonhfvud, Asa
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Libbrecht, Sasha
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Marton, Tamas
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McEntagart, Noel
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Molina, James T.
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Morotti, Raffael ...
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Nadal, Alfons
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Navarro, Alexand ...
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Nelander, Maria
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Oviedo, Angelica
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Oyamada Otani, A ...
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Papadogiannakis, ...
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Petersen, Astrid ...
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Roberts, Drucill ...
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Saad, Ali G.
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Sand, Anna
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Schoenmakers, Sa ...
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Sehn, Jennifer K ...
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Simpson, Preston ...
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Thomas, Kristen
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Yolotzin Valdesp ...
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van der Meeren, ...
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Van Dorpe, Jo
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Verdijk, Robert ...
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Watkins, Jaclyn ...
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Zaigham, Mehreen
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Archives of Path ...
- By the university
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Linköping University
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Karolinska Institutet