Parental TB associated with offspring asthma and rhinitis

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Lopez-Cervantes, J. P.Univ Bergen, Norway; Haukeland Hosp, Norway (author)

Parental TB associated with offspring asthma and rhinitis

Article/chapterEnglish2022

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Paris, France :International Union Against Tuberculosis and Lung Disease,2022
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LIBRIS-ID:oai:DiVA.org:liu-186839
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-186839URI
https://doi.org/10.5588/ijtld.21.0603DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies: Research Council of Norway Toppforsk Programme, Oslo, Norway [274767]
BACKGROUND: Infections in early life are associated with asthma and allergies in one-generation settings; however, the link between parental infection and offspring phenotype is rarely investigated. We aim to study the association of parental TB before conception of the offspring with offspring asthma and rhinitis.METHODS: We included 2,965 offspring born in 1985- 2004 and registered in the Norwegian prescription database to 1,790 parents born after 1960 with a history of TB, and included in the Norwegian TB registry. Offspring asthma (n = 582) and rhinitis (n = 929) were defined based on diagnosis, type of medication and prescribed medication >1 year. Associations of parental TB ,8 years, >8 years but before offsprings birth year and after birth (reference category) with offspring asthma and rhinitis were analysed using logistic regression.RESULTS: Asthma risk was higher in persons with parental TB in childhood (OR 1.73, 95% CI 1.20- 2.50) or later preconception (OR 1.38, 95% CI 1.00- 1.91) than in persons with parental TB after offsprings birth; this was significant only in the maternal line (childhood: OR 1.95, 95% CI 1.13-3.37; later precon-ception: OR 1.74, 95% CI 1.08-2.80). Associations with rhinitis were not identified.CONCLUSIONS: Parental childhood TB was associated with higher asthma risk in future offspring. We speculate that TB impacts maternal immunity , dysregulates the offsprings type 2 immunity , that TB-induced epigenetic reprograming of immune defences are trans-ferred to the offspring.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
infections; preconception; intergenera-tional; NCDs

Added entries (persons, corporate bodies, meetings, titles ...)

Shigdel, R.Univ Bergen, Norway (author)
Accordini, S.Univ Verona, Italy (author)
Mustafa, T.Univ Bergen, Norway (author)
Bertelsen, R. J.Univ Bergen, Norway (author)
Makvandi-Nejad, S.Univ Bergen, Norway; Haukeland Hosp, Norway (author)
Lerm, Maria,Professor,1973-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marle69 (author)
Horsnell, W.Univ Cape Town, South Africa; Univ Birmingham, England (author)
Svanes, C.Univ Bergen, Norway; Haukeland Hosp, Norway (author)
Univ Bergen, Norway; Haukeland Hosp, NorwayUniv Bergen, Norway (creator_code:org_t)

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In:The International Journal of Tuberculosis and Lung DiseaseParis, France : International Union Against Tuberculosis and Lung Disease26:6, s. 544-5491027-37191815-7920

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By the author/editor: Lopez-Cervantes, ...; Shigdel, R.; Accordini, S.; Mustafa, T.; Bertelsen, R. J.; Makvandi-Nejad, ...; show more...; Lerm, Maria, Pro ...; Horsnell, W.; Svanes, C.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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By the university: Linköping University

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