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Scene memory and hi...
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Gervais, Nicole J.Univ Toronto, Canada; Rotman Res Inst, Canada
(författare)
Scene memory and hippocampal volume in middle-aged women with early hormone loss
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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ELSEVIER SCIENCE INC,2022
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-187288
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187288URI
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https://doi.org/10.1016/j.neurobiolaging.2022.05.003DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies|Wilfred and Joyce Posluns Chair in Womens Brain Health and Aging; Alzheimers Association Research Fellowship; Brain Canada Foundation [WJP-150643]; Canadian Institutes of Health Research (CIHR); CIHR Masters award [AARF-17-504715]; Canadian Cancer Society [CAN 163902, MOP-143311, PJT-162292]; Ontario Brain Institute; Alzheimers Society of Canada [310336]; Natural Sciences and Engineering Research Council of Canada (NSERC); Womens Brain Health Initiative; Jacqueline Ford Gender and Health Fund [RGPIN-2017-06178]; NSERC Postgraduate Scholarships Doctoral Award; Ontario Graduate Scholarship award; General Motors Women in Science and Mathematics Award [PGSD3-546 6 67-2020]
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The present study explored whether early midlife bilateral salpingo-oophorectomy (BSO), a female specific risk factor for dementia, is associated with reduced medial temporal lobe structure and function. Younger middle-aged women with the BRCA1/2 mutation and a BSO prior to spontaneous menopause (SM) were recruited. We determined the performance of women with BSO not taking estradiol-based hormone therapy ( n = 18) on a task measuring object and scene recognition and quantified medial temporal lobe subregion volumes using manually segmented high-resolution T2-weighted MRI scans. Comparisons were made to those with BSO taking estradiol-based hormone therapy ( n = 20), age-matched premenopausal controls ( n = 28), and older women in SM not taking hormone therapy matched for duration of hormone deprivation ( n = 17). Reduced hippocampal integrity specific to the BSO group not taking hormone therapy was observed, reflected by significantly smaller dentate gyrus/CA2/CA3 volumes and lower scene recognition memory performance. These findings show that hippocampal subfield volume may be useful for identifying early midlife changes in women at elevated risk for dementia.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gravelsins, LauraUniv Toronto, Canada
(författare)
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Brown, AlanaUniv Toronto, Canada
(författare)
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Reuben, RebekahUniv Toronto, Canada
(författare)
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Karkaby, LauriceUniv Toronto, Canada
(författare)
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Baker-Sullivan, ElizabethUniv Toronto, Canada
(författare)
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Mendoza, LeanneUniv Toronto, Canada
(författare)
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Lauzon, ClaireUniv Toronto, Canada
(författare)
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Almey, AnneUniv Toronto, Canada; McGill Univ, Canada
(författare)
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Foulkes, William D.McGill Univ, Canada; Jewish Gen Hosp, Canada
(författare)
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Bernardini, Marcus Q.Univ Hlth Network, Canada
(författare)
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Jacobson, MichelleUniv Hlth Network, Canada
(författare)
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Velsher, LeaNorth York Gen Hosp, Canada
(författare)
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Rajah, M. NatashaMcGill Univ, Canada
(författare)
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Olsen, Rosanna K.Univ Toronto, Canada; Rotman Res Inst, Canada
(författare)
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Grady, CherylUniv Toronto, Canada; Rotman Res Inst, Canada; Univ Toronto, Canada
(författare)
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Einstein, GillianLinköpings universitet,Tema Genus,Filosofiska fakulteten,Univ Toronto, Canada; Rotman Res Inst, Canada; Womens Coll Res Inst, Canada(Swepub:liu)gilei02
(författare)
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Univ Toronto, Canada; Rotman Res Inst, CanadaUniv Toronto, Canada
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neurobiology of Aging: ELSEVIER SCIENCE INC117, s. 97-1060197-45801558-1497
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Gervais, Nicole ...
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Gravelsins, Laur ...
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Brown, Alana
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Reuben, Rebekah
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Karkaby, Laurice
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Mendoza, Leanne
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Lauzon, Claire
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Velsher, Lea
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