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Objective Observer ...
Objective Observer vs. Patient Motor State Assessments Using the PD Home Diary in Advanced Parkinsons Disease
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- Timpka, Jonathan (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Löhle, Matthias (författare)
- Univ Rostock, Germany; German Ctr Neurodegenerat Dis DZNE Rostock Greifsw, Germany,University of Rostock,German Center for Neurodegenerative Diseases (DZNE), Greifswald
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- Bremer, Alexander (författare)
- Univ Rostock, Germany; German Ctr Neurodegenerat Dis DZNE Rostock Greifsw, Germany,German Center for Neurodegenerative Diseases (DZNE), Greifswald,University of Rostock
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- Christiansson, Sofia (författare)
- Lund Univ, Sweden; Skane Univ Hosp, Sweden,Lund University Cancer Center,Skåne University Hospital
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- Gandor, Florin (författare)
- Movement Disorders Clin, Germany; Otto von Guericke Univ, Germany,'Somnus' Sleep and Movement Disorders Clinic,Otto von Guericke University Magdeburg
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- Ebersbach, Georg (författare)
- Movement Disorders Clin, Germany,'Somnus' Sleep and Movement Disorders Clinic
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- Dahlström, Örjan (författare)
- Linköping University,Linköpings universitet,Psykologi,Filosofiska fakulteten,Athletics Research Center
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- Iwarsson, Susanne (författare)
- Lund University,Lunds universitet,Aktivt och hälsosamt åldrande,Forskargrupper vid Lunds universitet,Nationella forskarskolan om åldrande och hälsa,Active and Healthy Ageing Research Group,Lund University Research Groups,National Graduate School on Ageing and Health,Lund Univ, Sweden
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- Nilsson, Maria H (författare)
- Lund University,Lunds universitet,Aktivt och hälsosamt åldrande,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,Active and Healthy Ageing Research Group,Lund University Research Groups,Clinical Memory Research,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Storch, Alexander (författare)
- Univ Rostock, Germany; German Ctr Neurodegenerat Dis DZNE Rostock Greifsw, Germany,German Center for Neurodegenerative Diseases (DZNE), Greifswald,University of Rostock
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- Odin, Per (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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(creator_code:org_t)
- 2022-07-12
- 2022
- Engelska.
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Ingår i: Frontiers in Neurology. - : Frontiers Media SA. - 1664-2295. ; 13
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: The Parkinson Disease (PD) Home Diary (HD) is a commonly used clinical outcome measure, but it has not been extensively compared to direct assessments by experienced observers. Objective: Validation of patient-reported HD by investigating the agreement between motor state assessments by patients and observers. Methods: This observational study included patients with PD and motor fluctuations. Observers were physicians or research nurses. Patients completed a screening visit, one day of diary ratings at home, and then two days of ratings on-site during which patients and observers simultaneously judged the participants motor state. Results: Observers and 40 patients completed 1,288 pairs of half-hourly blinded motor state assessments. There were significant differences between observer and patient ratings (P < 0.001) and the temporal agreement was poor (Cohens kappa = 0.358). The agreement between patient and observer ratings was 71.1% for observed "On without dyskinesia", 57.3% for observed "Off", and 49.4% for observed "On with dyskinesia". Daily times spent in the three motor states as aggregated diary data showed fair to excellent reliability with intraclass coefficient values ranging from 0.45 to 0.52 for "On" and 0.77 for "Off". Conclusion: There were significant differences between observer and patient ratings. Patients and observers generally agreed on when the patients was in the "On" state (with or without dyskinesia). Patient ratings on the hour level seem to be influenced by other aspects of the patients experience than the observed motor state, but assessment of daily time spent in the different motor state provides reasonable reliability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- motor fluctuations; Parkinson disease; patient reported outcome (PRO) measures; clinical trials; Parkinson disease home diary
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- ref (ämneskategori)
- art (ämneskategori)
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Timpka, Jonathan
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Löhle, Matthias
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Bremer, Alexande ...
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Christiansson, S ...
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Gandor, Florin
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Ebersbach, Georg
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Dahlström, Örjan
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Iwarsson, Susann ...
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Nilsson, Maria H
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Storch, Alexande ...
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Odin, Per
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Frontiers in Neu ...
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