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  • Beck, DaniUniv Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, Norway (author)

Adipose tissue distribution from body MRI is associated with cross-sectional and longitudinal brain age in adults

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier Science Ltd,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-187591
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187591URI
  • https://doi.org/10.1016/j.nicl.2022.102949DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Research Council of Norway [223273, 249795, 248238, 276082]; South-Eastern Norway Regional Health Authority [2014097, 2015044, 2015073, 2016083, 2018037, 2018076]; Norwegian ExtraFoundation for Health and Rehabilitation [2015/FO5146]; KG Jebsen Stiftelsen; Swiss National Science Foundation [PZ00P3_193658]; German Federal Ministry of Education and Research (BMBF) [01ZX1904A]; ERA-Net Cofund through the ERA PerMed project IMPLEMENT (Research Council of Norway) [298646]; European Research Council under the European Unions Horizon 2020 Research and Innovation program (ERC StG) [802998, 847776]
  • There is an intimate body-brain connection in ageing, and obesity is a key risk factor for poor cardiometabolic health and neurodegenerative conditions. Although research has demonstrated deleterious effects of obesity on brain structure and function, the majority of studies have used conventional measures such as waist-to-hip ratio, waist circumference, and body mass index. While sensitive to gross features of body composition, such global anthropometric features fail to describe regional differences in body fat distribution and composition. The sample consisted of baseline brain magnetic resonance imaging (MRI) acquired from 790 healthy participants aged 18-94 years (mean +/- standard deviation (SD) at baseline: 46.8 +/- 16.3), and follow-up brain MRI collected from 272 of those individuals (two time-points with 19.7 months interval, on average (min = 9.8, max = 35.6). Of the 790 included participants, cross-sectional body MRI data was available from a subgroup of 286 participants, with age range 19-86 (mean = 57.6, SD = 15.6). Adopting a mixed cross-sectional and longitudinal design, we investigated cross-sectional body magnetic resonance imaging measures of adipose tissue distribution in relation to longitudinal brain structure using MRI-based morphometry (T1) and diffusion tensor imaging (DTI). We estimated tissue-specific brain age at two time points and performed Bayesian multilevel modelling to investigate the associations between adipose measures at follow-up and brain age gap (BAG) - the difference between actual age and the prediction of the brains biological age - at baseline and follow-up. We also tested for interactions between BAG and both time and age on each adipose measure. The results showed credible associations between T1-based BAG and liver fat, muscle fat infiltration (MFI), and weight-to-muscle ratio (WMR), indicating older-appearing brains in people with higher measures of adipose tissue. Longitudinal evidence supported interaction effects between time and MFI and WMR on T1-based BAG, indicating accelerated ageing over the course of the study period in people with higher measures of adipose tissue. The results show that specific measures of fat distribution are associated with brain ageing and that different compartments of adipose tissue may be differentially linked with increased brain ageing, with potential to identify key processes involved in age-related transdiagnostic disease processes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • De Lange, Ann-Marie G.Univ Oslo, Norway; Univ Oslo, Norway; CHU Vaudois, Switzerland; Univ Lausanne, Switzerland; Univ Oxford, England (author)
  • Alnaes, DagUniv Oslo, Norway; Univ Oslo, Norway; Bjorknes Coll, Norway (author)
  • Maximov, Ivan I.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Western Norway Univ Appl Sci, Norway (author)
  • Pedersen, Mads L.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway (author)
  • Dahlqvist Leinhard, Olof,1978-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Med AB, Linkoping, Sweden(Swepub:liu)oloda24 (author)
  • Linge, JenniferLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,AMRA Med AB, Linkoping, Sweden(Swepub:liu)jenli83 (author)
  • Simon, RozalynLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,AMRA Med AB, Linkoping, Sweden(Swepub:liu)rozsi29 (author)
  • Richard, GenevieveUniv Oslo, Norway; Univ Oslo, Norway (author)
  • Ulrichsen, Kristine M.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, Norway (author)
  • Dorum, Erlend S.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, Norway (author)
  • Kolskår, Knut K.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, Norway (author)
  • Sanders, Anne-MartheUniv Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, Norway (author)
  • Winterton, AdrianoUniv Oslo, Norway; Univ Oslo, Norway (author)
  • Gurholt, Tiril P.Univ Oslo, Norway; Univ Oslo, Norway (author)
  • Kaufmann, TobiasUniv Oslo, Norway; Univ Oslo, Norway; Univ Tubingen, Germany (author)
  • Steen, Nils EielUniv Oslo, Norway; Univ Oslo, Norway (author)
  • Nordvik, Jan EgilCatoSenteret Rehabil Ctr, Norway (author)
  • Andreassen, Ole A.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway (author)
  • Westlye, Lars T.Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway (author)
  • Univ Oslo, Norway; Univ Oslo, Norway; Univ Oslo, Norway; Sunnaas Rehabil Hosp HT, NorwayUniv Oslo, Norway; Univ Oslo, Norway; CHU Vaudois, Switzerland; Univ Lausanne, Switzerland; Univ Oxford, England (creator_code:org_t)

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