Search: id:"swepub:oai:DiVA.org:liu-188153" >
Plasma protein prof...
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Papapavlou Lingehed, GeorgiaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
(author)
Plasma protein profiling reveals dynamic immunomodulatory changes in multiple sclerosis patients during pregnancy
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-07-29
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Frontiers Media SA,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-188153
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-188153URI
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https://doi.org/10.3389/fimmu.2022.930947DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150499821URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Foundation for Strategic Research [SB16-0011]; Swedish Research Council [2018-02776, 2021-03092]; Medical Research Council of Southeast Sweden [FORSS-315121]; NEURO Sweden [F2018-0052]; ALF grants; Region OEstergoetland; Swedish Foundation
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Multiple sclerosis (MS) is a chronic autoimmune neuroinflammatory and neurodegenerative disorder of the central nervous system. Pregnancy represents a natural modulation of the disease course, where the relapse rate decreases, especially in the 3(rd) trimester, followed by a transient exacerbation after delivery. Although the exact mechanisms behind the pregnancy-induced modulation are yet to be deciphered, it is likely that the immune tolerance established during pregnancy is involved. In this study, we used the highly sensitive and specific proximity extension assay technology to perform protein profiling analysis of 92 inflammation-related proteins in MS patients (n=15) and healthy controls (n=10), longitudinally sampled before, during, and after pregnancy. Differential expression analysis was performed using linear models and p-values were adjusted for false discovery rate due to multiple comparisons. Our findings reveal gradual dynamic changes in plasma proteins that are most prominent during the 3(rd) trimester while reverting post-partum. Thus, this pattern reflects the disease activity of MS during pregnancy. Among the differentially expressed proteins in pregnancy, several proteins with known immunoregulatory properties were upregulated, such as PD-L1, LIF-R, TGF-beta 1, and CCL28. On the other hand, inflammatory chemokines such as CCL8, CCL13, and CXCL5, as well as members of the tumor necrosis factor family, TRANCE and TWEAK, were downregulated. Further in-depth studies will reveal if these proteins can serve as biomarkers in MS and whether they are mechanistically involved in the disease amelioration and worsening. A deeper understanding of the mechanisms involved may identify new treatment strategies mimicking the pregnancy milieu.
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Hellberg, SandraLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)sanhe13
(author)
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Huang, JesseKarolinska Univ Hosp, Sweden
(author)
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Khademi, MohsenKarolinska Institutet,Karolinska Univ Hosp, Sweden
(author)
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Kockum, IngridKarolinska Institutet,Karolinska Univ Hosp, Sweden
(author)
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Carlsson, HannaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,4Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County, Kalmar, Sweden(Swepub:liu)hanca82
(author)
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Tjernberg, IvarLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,4Department of Clinical Chemistry and Transfusion Medicine, Region Kalmar County, Kalmar, Sweden(Swepub:liu)ivatj55
(author)
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Svenvik, MariaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Dept Obstet & Gynecol, Sweden(Swepub:liu)marsv62
(author)
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Lind, JonasLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Cty Hosp Ryhov, Sweden(Swepub:liu)jonli23
(author)
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Blomberg, MarieLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)marce21
(author)
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Vrethem, MagnusLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)magvr07
(author)
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Mellergård, JohanLinköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)johme15
(author)
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Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75
(author)
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Jenmalm, MariaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marje18
(author)
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Olsson, TomasKarolinska Institutet,Karolinska Univ Hosp, Sweden
(author)
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Ernerudh, JanLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(author)
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Linköpings universitetAvdelningen för inflammation och infektion
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In:Frontiers in Immunology: Frontiers Media SA131664-3224
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Papapavlou Linge ...
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Hellberg, Sandra
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Huang, Jesse
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Khademi, Mohsen
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Kockum, Ingrid
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Carlsson, Hanna
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Tjernberg, Ivar
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Svenvik, Maria
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Lind, Jonas
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Blomberg, Marie
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Vrethem, Magnus
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Mellergård, Joha ...
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Gustafsson, Mika
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Jenmalm, Maria
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Olsson, Tomas
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Ernerudh, Jan
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